Nanotherapy for posterior eye diseases

IP Kaur, S Kakkar - Journal of Controlled Release, 2014 - Elsevier
It is assumed that more than 50% of the most enfeebling ocular diseases have their origin in
the posterior segment. Furthermore, most of these diseases lead to partial or complete …

Nanoemulsions—advances in formulation, characterization and applications in drug delivery

SA Chime, FC Kenechukwu… - … of nanotechnology in drug …, 2014 - books.google.com
An ideal drug delivery system fulfils the objective of maximizing therapeutic effect while
minimizing toxicity. With the progress in time and advances in science and technology …

Preclinical formulations: insight, strategies, and practical considerations

SM Shah, AS Jain, R Kaushik, MS Nagarsenker… - Aaps Pharmscitech, 2014 - Springer
A lot of resources and efforts have been directed to synthesizing potentially useful new
chemical entities (NCEs) by pharmaceutical scientists globally. Detailed physicochemical …

Optimization of curcumin nanoemulsion for intranasal delivery using design of experiment and its toxicity assessment

S Sood, K Jain, K Gowthamarajan - Colloids and Surfaces B: Biointerfaces, 2014 - Elsevier
The objective of the study was to optimize curcumin nanoemulsion for intranasal delivery
using design of experiment. Box–Behnken design was constructed using oil, surfactant and …

Preparation and in vitro–in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment …

N Üstündağ-Okur, EH Gökçe, Dİ Bozbıyık… - European Journal of …, 2014 - Elsevier
The objective of this study was to explore the potential of the nanostructured lipid carriers
(NLCs) modified with chitosan oligosaccharide lactate (COL) for topical ocular application …

A nanoparticle formulation reduces the corneal toxicity of indomethacin eye drops and enhances its corneal permeability

N Nagai, Y Ito, N Okamoto, Y Shimomura - Toxicology, 2014 - Elsevier
Indomethacin (IMC) has been shown to reduce post-operative inflammation and to decrease
intraocular irritation after cataract extraction and in cystoid macular edema; however, the …

Novel ofloxacin-loaded microemulsion formulations for ocular delivery

N Üstündag-Okur, EH Gökçe, S Eğrilmez… - Journal of ocular …, 2014 - liebertpub.com
Purpose: The aim of this study was to prepare a novel oil-in-water microemulsion of
ofloxacin (OFX) for topical ocular application. Methods: Pseudo-ternary phase diagrams …

Anti HIV nanoemulsion formulation: optimization and in vitro–in vivo evaluation

S Kotta, AW Khan, SH Ansari, RK Sharma… - International Journal of …, 2014 - Elsevier
The objective of the present work is to develop a dose adjustable nanotechnology based
liquid formulation of efavirenz with improved bioavailability for HIV therapy. Nanoemulsion of …

[PDF][PDF] Nanoemulsion as a novel ophthalmic delivery system for acetazolamide

NM Morsi, MI Mohamed, H Refai… - Int. J. Pharm. Pharm …, 2014 - core.ac.uk
Objective: The aim of this work was to formulate the antiglaucoma drug acetazolamide as
ocular nanoemulsion of high therapeutic efficacy and prolonged effect. Methods: Eighteen …

A novel polyethylene glycol mediated lipid nanoemulsion as drug delivery carrier for paclitaxel

X Jing, L Deng, B Gao, L Xiao, Y Zhang, X Ke… - … , Biology and Medicine, 2014 - Elsevier
A novel polyethylene glycol 400 (PEG400) mediated lipid nanoemulsion as drug-delivery
carrier for paclitaxel (PTX) was successfully developed. The formulation comprised a …