Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …

Over three decades have passed since the first report on the expression of CA125 by
ovarian tumors. Since that time our understanding of ovarian cancer biology has changed …

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …

The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate
cancer has hampered progress in understanding disease pathogenesis and therapy …

Recent genomic analyses of pathologically defined tumor types identify" within-a-tissue"
disease subtypes. However, the extent to which genomic signatures are shared across …

Extensive genomic characterization of human cancers presents the problem of inference
from genomic abnormalities to cancer phenotypes. To address this problem, we analysed …

Background Maintenance monotherapy with the PARP inhibitor olaparib significantly
prolonged progression-free survival (PFS) versus placebo in patients with platinum-sensitive …

Human cancer genomes harbour a variety of alterations leading to the deregulation of key
pathways in tumour cells. The genomic characterization of tumours has uncovered …

Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers. We
performed exome sequencing on 113 tumor-normal pairs, yielding a mean of 82 non-silent …

We performed massively parallel sequencing of paired tumor/normal samples from 203
multiple myeloma (MM) patients and identified significantly mutated genes and copy number …