Association of cyclooxygenase-2 genetic variant with cardiovascular disease

S Ross, J Eikelboom, SS Anand… - European heart …, 2014 - academic.oup.com
Aim A genetic variant (rs20417) of the PTGS2 gene, encoding for COX-2, has been
associated with decreased COX-2 activity and a decreased risk of cardiovascular disease …

Analysis of interleukin-8 gene variants reveals their relative importance as genetic susceptibility factors for chronic periodontitis in the Han population

N Zhang, Y Xu, B Zhang, T Zhang, H Yang, B Zhang… - PLoS …, 2014 - journals.plos.org
Interleukin (IL)-8, an important chemokine that regulates the inflammatory response, plays
an important role in periodontitis. Previous studies indicate that certain IL-8 gene …

-765 G> C Polymorphism of the COX-2 gene and gastric cancer risk in Brazilian population

VMLP Campanholo, AV Felipe, JM LIMA… - Arquivos de …, 2014 - SciELO Brasil
Context Genomic alterations play important roles in gastric cancer carcinogenesis.
Cyclooxygenases (COX) are important enzymes in the maintenance of mucosal integrity and …

糖尿病状态下阿司匹林抵抗的研究进展

谢昊, 朱语眉, 郝海平, 郑啸… - … 临床药理学与治疗学, 2014 - manu41.magtech.com.cn
阿司匹林作为抗血小板聚集治疗的“金标准”, 在预防心脑血管栓塞性疾病方面起着重要的作用.
然而在服用阿司匹林后, 并非所有的患者均能获得一致的抗血小板聚集效益. 临床上 …

The thrombotic and arrhythmogenic risks of perioperative NSAIDs

NS Gerstein, WH Gerstein, MC Carey… - … of cardiothoracic and …, 2014 - jcvaonline.com
Address reprint requests to Neal Stuart Gerstein, MD, Department of Anesthesiology, MSC
10 6000, 2211 Lomas Blvd NE University of New Mexico, Albuquerque, NM 87120. E-mail …

Cardiovascular pharmacogenetics of anti-thrombotic agents and non-steroidal anti-inflammatory drugs

J Stitham, P Vanichakarn, L Ying… - Current Molecular …, 2014 - ingentaconnect.com
The use of antithrombotic agents, particularly antiplatelet drugs like aspirin and clopidogrel,
has been instrumental in decreasing the risk for adverse cardiovascular events across a …

[PDF][PDF] PTGS2 gene polymorphism-765G> C is associated with coronary artery disease: a meta-analysis

CL Xuan, W Yan, L Xuan, RH Xu - Genet Mol Res, 2014 - geneticsmr.com
Previous studies focusing on the association of PTGS2 polymorphism-765G> C with
coronary artery disease (CAD) have failed to reach the same conclusion. In the present …

Association between polymorphism c. 1-765G> C of the COX2 gene and cognitive impairment in individuals 65 years or more with diabetes from a Geriatric Service in …

EDDL González, HG Hermosillo, JAC Rodrígez… - Medicina clinica, 2014 - Elsevier
Background and objective Cognitive impairment and dementia are common geriatric
syndromes in diabetic patients. Inflammation plays a crucial role in the pathophysiology of …

[引用][C] 环氧化酶1 与2 基因多态性与缺血性脑卒中患者阿司匹林抵抗的相关性研究

彭玲玲, 蔡业峰, 招远祺, 李嘉丽, 周子懿, 金晶, 黄民 - 中国临床药理学杂志, 2014

[引用][C] 环氧合酶2 基因单核苷酸多态性与慢性阻塞性肺疾病相关性研究

崔德月, 周军, 秦莉, 罗光华 - 临床荟萃, 2014