Recent developments in genetics/genomics of osteoarthritis (OA) are discussed to improve
our understanding of OA pathophysiology. The discovery of a novel variant near the NCOA3 …

Epigenetics refers to the study of mechanisms able to influence gene expression in a stable
and potentially heritable manner without altering the DNA sequence. These mechanisms …

Ancient DNA sequencing has recently provided high-coverage archaic human genomes.
However, the evolution of epigenetic regulation along the human lineage remains largely …

Objective Alterations in DNA methylation patterns have been found to correlate with several
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …

Dr. Chen or an immediate family member has received research or institutional support from
Amgen. Neither Dr. Shen nor any immediate family member has received anything of value …

Methods A Medline search was performed in March of 2013 to identify relevant genetic
studies of OCD in all animals and humans (Fig. 1). Searches were performed for both …

The pathogenesis of osteoarthritis (OA) involves cartilage degradation, synovial
inflammation, subchondral bone sclerosis, degeneration of ligaments and meniscus, and …

Epigenetic regulation utilizes different mechanisms to convey heritable traits to progeny cells
that are independent of DNA sequence, including DNA silencing, post-translational …

Objectives Rheumatic diseases encompass a wide range of conditions of poorly
characterized etiopathology, many having both genetic and environmental susceptibility …

Osteoporosis is a prevalent disease that typically reduces bone strength and predisposes to
fractures. It is a multifactorial disorder resulting from the interaction of genetic and acquired …