Epigenetic-based therapies for Friedreich ataxia
C Sandi, M Sandi, S Anjomani Virmouni… - Frontiers in …, 2014 - frontiersin.org
Friedreich ataxia (FRDA) is a lethal autosomal recessive neurodegenerative disorder
caused primarily by a homozygous GAA repeat expansion mutation within the first intron of …
caused primarily by a homozygous GAA repeat expansion mutation within the first intron of …
A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease
MR Smith, A Syed, T Lukacsovich… - Human molecular …, 2014 - academic.oup.com
Protein acetylation, which is central to transcriptional control as well as other cellular
processes, is disrupted in Huntington's disease (HD). Treatments that restore global …
processes, is disrupted in Huntington's disease (HD). Treatments that restore global …
p53 prevents neurodegeneration by regulating synaptic genes
DNA damage has been implicated in neurodegenerative disorders, including Alzheimer's
disease and other tauopathies, but the consequences of genotoxic stress to postmitotic …
disease and other tauopathies, but the consequences of genotoxic stress to postmitotic …
Drosophila Myc, a novel modifier suppresses the poly (Q) toxicity by modulating the level of CREB binding protein and histone acetylation
MD Singh, K Raj, S Sarkar - Neurobiology of Disease, 2014 - Elsevier
Polyglutamine or poly (Q) disorders are dominantly inherited neurodegenerative diseases
characterised by progressive loss of neurons in cerebellum, basal ganglia and cortex in …
characterised by progressive loss of neurons in cerebellum, basal ganglia and cortex in …
Caracterización de genes nuevos involucrados en neurodegeneración en Drosophila melanogaster
G Bernabó - 2014 - bibliotecadigital.exactas.uba.ar
El objetivo de esta tesis es identificar nuevos genes involucrados enneurodegeneración en
Drosophila melanogaster y comprender su función y elmecanismo por el cual provoca dicha …
Drosophila melanogaster y comprender su función y elmecanismo por el cual provoca dicha …
Estudio de la toxicidad diferencial causada por péptidos amiloides asociados a enfermedades neurodegenerativas en Drosophila melanogaster
MS Marcora - 2014 - bibliotecadigital.exactas.uba.ar
La enfermedad de Alzheimer (EA) y las demencias familiares Británica (DFB) y Danesa
(DFD) se caracterizan por la acumulación progresiva de péptidos amiloides yproteína tau …
(DFD) se caracterizan por la acumulación progresiva de péptidos amiloides yproteína tau …