Autophagy and apoptosis control the turnover of organelles and proteins within cells, and of
cells within organisms, respectively, and many stress pathways sequentially elicit …

Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

Mammalian cell homeostasis during starvation depends on initiation of autophagy by
endoplasmic reticulum-localized phosphatidylinositol 3-phosphate (PtdIns (3) P) synthesis …

Cells rely on autophagy to clear misfolded proteins and damaged organelles to maintain
cellular homeostasis. In this study we use the new autophagy inhibitor PIK-III to screen for …

Mitochondrial dysfunction has long been associated with P arkinson's disease (PD). Parkin
and PINK 1, two genes associated with familial PD, have been implicated in the degradation …

Mitochondrial dysfunction is a common feature in neurodegeneration and aging. We identify
mitochondrial dysfunction in xeroderma pigmentosum group A (XPA), a nucleotide excision …

Autophagy is an evolutionarily conserved catabolic process that recycles nutrients upon
starvation and maintains cellular energy homeostasis,,. Its acute regulation by nutrient …

The pathogenic mechanisms underlying the progression of non-alcoholic fatty liver disease
(NAFLD) are not fully understood. In this study, we aimed to assess the relationship between …

Mitochondrial autophagy, or mitophagy, is a major mechanism involved in mitochondrial
quality control via selectively removing damaged or unwanted mitochondria. Interactions …

Vps34 is a phosphoinositide 3-kinase (PI3K) class III isoform that has attracted major
attention over the recent years because of its role in autophagy. Herein we describe the …