Aquaporins in the eye: expression, function, and roles in ocular disease
KL Schey, Z Wang, JL Wenke, Y Qi - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
Background All thirteen known mammalian aquaporins have been detected in the eye.
Moreover, aquaporins have been identified as playing essential roles in ocular functions …
Moreover, aquaporins have been identified as playing essential roles in ocular functions …
Aquaporin-0 targets interlocking domains to control the integrity and transparency of the eye lens
WK Lo, SK Biswas, L Brako, A Shiels… - … & visual science, 2014 - iovs.arvojournals.org
Purpose.: Lens fiber cell membranes contain aquaporin-0 (AQP0), which constitutes
approximately 50% of the total fiber cell membrane proteins and has a dual function as a …
approximately 50% of the total fiber cell membrane proteins and has a dual function as a …
Aquaporin 0 plays a pivotal role in refractive index gradient development in mammalian eye lens to prevent spherical aberration
SS Kumari, K Varadaraj - Biochemical and biophysical research …, 2014 - Elsevier
Abstract Aquaporin 0 (AQP0) is a transmembrane channel that constitutes∼ 45% of the total
membrane protein of the fiber cells in mammalian lens. It is critical for lens transparency and …
membrane protein of the fiber cells in mammalian lens. It is critical for lens transparency and …
Intact and N-or C-terminal end truncated AQP0 function as open water channels and cell-to-cell adhesion proteins: end truncation could be a prelude for adjusting the …
SS Kumari, K Varadaraj - Biochimica et Biophysica Acta (BBA)-General …, 2014 - Elsevier
Background Investigate the impact of natural N-or C-terminal post-translational truncations
of lens mature fiber cell Aquaporin 0 (AQP0) on water permeability (Pw) and cell-to-cell …
of lens mature fiber cell Aquaporin 0 (AQP0) on water permeability (Pw) and cell-to-cell …
A novel MIP gene mutation analysis in a Chinese family affected with congenital progressive punctate cataract
X Ding, N Zhou, H Lin, J Chen, C Zhao, G Zhou… - PloS one, 2014 - journals.plos.org
Congenital cataracts are one of the leading causes of visual impairment and blindness in
children, and genetic factors play an important role in their development. This study aimed to …
children, and genetic factors play an important role in their development. This study aimed to …
The kinetics of thermal stress induced denaturation of Aquaporin 0
JE Hansen, L Leslie, S Swamy-Mruthinti - Biochemical and Biophysical …, 2014 - Elsevier
Abstract Aquaporin 0 (AQP0) is an integral membrane protein that facilitates water transport
and cellular adhesion in the lens. Its dysfunction has been associated with cataractogenesis …
and cellular adhesion in the lens. Its dysfunction has been associated with cataractogenesis …