A virtual reality task based on animal research–spatial learning and memory in patients after the first episode of schizophrenia

I Fajnerová, M Rodriguez, D Levčík… - Frontiers in behavioral …, 2014 - frontiersin.org
Objectives: Cognitive deficit is considered to be a characteristic feature of schizophrenia
disorder. A similar cognitive dysfunction was demonstrated in animal models of …

[PDF][PDF] Spatial navigation: implications for animal models, drug development and human studies.

A Stuchlik, S Kubik, K Vlcek, K Vales - Physiological Research, 2014 - biomed.cas.cz
Spatial navigation and memory is considered to be a part of the declarative memory system
and it is widely used as an animal model of human declarative memory. However, spatial …

Co-administration of 5-HT6 receptor antagonists with clozapine, risperidone, and a 5-HT2A receptor antagonist: effects on prepulse inhibition in rats

K Fijał, P Popik, A Nikiforuk - Psychopharmacology, 2014 - Springer
Rationale Some novel antipsychotics manifest antagonistic activity at serotonin-6 receptors;
however, little is known about the role of 5-HT6 receptors in ameliorating sensory gating …

Pyrroloquinoline quinone prevents MK-801-induced stereotypical behavior and cognitive deficits in mice

X Zhou, Q Chen, X Hu, S Mao, Y Kong - Behavioural brain research, 2014 - Elsevier
Pyrroloquinoline quinone (PQQ), an essential nutrient, antioxidant, redox modulator, and
nerve growth factor, prevents cognitive deficits associated with oxidative stress-induced …

Antagonism of the adenosine A2A receptor attenuates akathisia-like behavior induced with MP-10 or aripiprazole in a novel non-human primate model

CJ Bleickardt, TM Kazdoba, NT Jones… - Pharmacology …, 2014 - Elsevier
Akathisia is a subset of the larger antipsychotic side effect profile known as extrapyramidal
syndrome (EPS). It is associated with antipsychotic treatment and is characterized as a …

Dopamine D2/D3 receptor binding of [123I] epidepride in risperidone-treatment chronic MK-801-induced rat schizophrenia model using nanoSPECT/CT …

YR Huang, CW Pai, KH Cheng, WI Kuo… - Nuclear Medicine and …, 2014 - Elsevier
Introduction Epidepride is a compound with an affinity in picomolar range for D 2/D 3
receptors. The aim of this work was designed to investigate the diagnostic possibility of [123 …