Prostate cancer (PCa) is the second most common malignancy among men in the world.
Castration-resistant prostate cancer (CRPC) is the lethal form of the disease, which …

When PI3K (phosphatidylinositol-3 kinase) is activated by receptor tyrosine kinases, it
phosphorylates PIP2 to generate PIP3 and activates the signaling pathway. Phosphatase …

Prostate cancer is the most commonly diagnosed malignancy among men in industrialized
countries, accounting for the second leading cause of cancer-related deaths. Although we …

The androgen receptor (AR) is expressed in many cell types and the androgen/AR signaling
has been found to have important roles in modulating tumorigenesis and metastasis in …

Chronic inflammation has been shown to promote the initiation and progression of diverse
malignancies by inducing genetic and epigenetic alterations. In this study, we investigate an …

Abstract The PI3K/Akt pathway is an actively pursued therapeutic target in oncology. In
prostate cancer, the activation of this pathway appears to be characteristic of many …

Forkhead box O (FoxO) transcription factors play an important role as tumor suppressor in
several human malignancies. Disruption of FoxO activity due to loss of phosphatase and …

Cancer cells display an increased demand for glucose. Therefore, identifying the specific
aspects of glucose metabolism that are involved in the pathogenesis of cancer may uncover …

Chronic inflammation is known to be associated with prostate cancer development, but how
epithelium-associated cancer-initiating events cross talk to inflammatory cells during …

Radiation therapy (RT) continues to be one of the most popular treatment options for
localized prostate cancer (CaP). Local CaP recurrence after RT is a pattern of treatment …