How to trigger a killer: modulation of natural killer cell reactivity on many levels

C Watzl - Advances in immunology, 2014 - Elsevier
Abstract The functions of Natural Killer (NK) cells are regulated by a highly redundant set of
germline-encoded surface receptors that can inhibit or activate NK cell activities. NK cells …

NK cell development and function–plasticity and redundancy unleashed

F Cichocki, E Sitnicka, YT Bryceson - Seminars in immunology, 2014 - Elsevier
Bone marrow-derived natural killer (NK) cells constitute the major subset of cytotoxic
lymphocytes in peripheral blood. They provide innate defense against intracellular infection …

Memory CD8+ T cells exhibit increased antigen threshold requirements for recall proliferation

ER Mehlhop-Williams, MJ Bevan - Journal of Experimental Medicine, 2014 - rupress.org
A hallmark of immunological memory is the ability of previously primed T cells to undergo
rapid recall responses upon antigen reencounter. Classic work has suggested that memory …

2013 年国内外免疫学研究重要进展

刘娟, 曹雪涛 - 中国免疫学杂志, 2014 - cqvip.com
悄然间已到笔者与读者共享年度免疫学研究重要前沿进展的第5 个年头. 5 年来,
免疫学的发展日新月异, 免疫学的基础性关键理论不断拓展和完善, 新型免疫学技术不断涌现与 …

CARD11 blockade suppresses murine collagen-induced arthritis via inhibiting CARD11/Bcl10 assembly and T helper type 17 response

H Wang, J Zhao, H Zhang, Y Huang… - Clinical & …, 2014 - academic.oup.com
The scaffold protein caspase recruitment domain-containing protein 11 (CARD11) is
implicated in the regulation of inflammation and autoimmunity. The present study aimed to …

Activation mechanisms of the SAP family adaptor EAT-2 in natural killer cells

LA Pérez-Quintero - 2014 - search.proquest.com
Natural killer (NK) cells express several members of the SLAM family of receptors. When
stimulated, these receptor molecules can inhibit or activate NK cell function. Ewing's …

[引用][C] Project Title Molecular Mechanism of CD137-mediated Apoptosis in Dengue Virus Infection and Its Application