Mammalian sex determination is the unique process whereby a single organ, the bipotential
gonad, undergoes a developmental switch that promotes its differentiation into either a testis …

Context: Disorders of sex development (DSDs) may arise from genetic defects in testis or
ovary determination. Current analytical technologies and improved understanding of major …

Gonadal sex differentiation proceeds by the interplay of various genes including the
transcription factors and secretory factors in a complex network. The sex-differentiating …

Abstract Background Cadmium (Cd) is a severe detrimental environmental pollutant. To
adapt to Cd-induced deleterious effects, plants have evolved sophisticated defence …

Background The green mud crab (Scylla paramamosain) is the most prevalent crustacean
on the southeast coast of China. The molecular regulatory mechanism of sex determination …

In-frame missense and splicing mutations (resulting in a 2 amino acid insertion or a 34
amino acid deletion) dispersed through the MAP3K1 gene tilt the balance from the male to …

Zebrafish males undergo a “juvenile ovary-to-testis” gonadal transformation process.
Several genes, including nuclear receptor subfamily 5, group A (nr5a) and anti-Müllerian …

One of the defining events during human embryonic development with the most far-reaching
effects for the individual is whether the embryo develops as male or female. The crucial step …

Abstract Background The Asian seabass (Lates calcarifer) is a protandrous hermaphrodite
that typically matures as a male at approximately 2–4 years of age and then changes sex in …

Wnt4 gene plays a role in developmental processes in mammals. However, little is known
regarding its function in teleosts. We cloned and characterized the full-length half-smooth …