The limited effectiveness of current therapies against Alzheimer's disease (AD) highlights
the need for intensifying research efforts devoted to developing new agents for preventing or …

The link between cannabis use and psychosis comprises three distinct relationships: acute
psychosis associated with cannabis intoxication; acute psychosis that lasts beyond the …

Long-term depression (LTD) of the efficacy of synaptic transmission is now recognized as an
important mechanism for the regulation of information storage and the control of actions, as …

The endocannabinoid system (ECS) is now recognised as an important modulator of various
central nervous system processes. More recently, an increasing body of evidence has …

Synaptic neuromodulation acts across different functional domains to regulate cognitive
processing and behavior. Recent challenges are related to elucidating the molecular and …

The level of the endocannabinoid anandamide is controlled by fatty acid amide hydrolase
(FAAH). In 2011, PF‐04457845, an irreversible inhibitor of FAAH, was progressed to phase …

Cannabinoids are key regulators of vascular tone, some of the mechanisms involved include
the activation of cannabinoid receptor types 1 and 2 (CB); the transient receptor potential …

The quest for possible targets for the development of novel analgesics has identified the
activation of the cannabinoid type 1 (CB 1) receptor outside the CNS as a potential means of …

Any unanticipated threat to survival triggers an immediate sequence of events in the brain
that culminate in a coordinated neural, endocrine and behavioural response. There is …

Activation of cannabinoid receptor type 1 on presynaptic neurons is postulated to suppress
neurotransmission by decreasing Ca 2+ influx through high voltage-gated Ca 2+ channels …