Effective management of procedural and postoperative pain in neonates is required to
minimize acute physiological and behavioral distress and may also improve acute and long …

Effective and safe drug administration in neonates should be based on integrated
knowledge on the evolving physiological characteristics of the infant who will receive the …

Historically, pain in the preterm infant has been poorly understood and often unrecognized.
1 There have been major advances in understanding the developmental physiology of …

Many factors contribute to suboptimal pain management in children. Current evidence
suggests that severe pain in children has significant long-lasting effects, even more so than …

Introduction Body temperature measurement in children is of clinical relevance. Although
rectal measurement is the gold standard, less invasive tools have become available. We …

Pain after thoracic surgery can be severe and, in the acute phase, contribute to perioperative
morbidity and mortality. Unfortunately, patients also incur a significant risk of chronic pain …

Abstract Background and Objectives From a previously validated paediatric population
pharmacokinetic model, it was derived that non-linear morphine maintenance doses of 5 …

Even with the rapid development of pediatric postoperative pain management, pediatric
patients have remained undertreated for postoperative pain because of difficulty in pain …

This paper is the thirty-sixth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2013 …

Background Clefting of the lip, palate, or both is a common congenital abnormality.
Inadequate treatment for pain in children may result from concerns over opioid‐related …