Mononuclear phagocytic cells in the CNS used to be defined according to their anatomical
location and surface marker expression. Recently, this concept has been challenged by the …

This paper summarizes pathological changes that affect microglial cells in the human brain
during aging and in aging-related neurodegenerative diseases, primarily Alzheimer's …

Macrophages are cellular components of the innate immune system that reside in virtually
all tissues and contribute to immunity, repair, and homeostasis. The traditional view that all …

Microglia are unique cells within the central nervous system because of their biophysical
independence. As a result of this unusual property the cells must undergo significant …

Primary brain tumours (gliomas) initiate a strong host response and can contain large
amounts of immune cells (myeloid cells) such as microglia and tumour-infiltrating …

Microglia are highly specialized tissue macrophages of the brain with dedicated functions in
neuronal development, homeostasis and recovery from pathology Despite their unique …

Microglia have long been the focus of much attention due to their strong proliferative
response (microgliosis) to essentially any kind of damage to the CNS. More recently, we …

Microglial cells contribute to normal function of the central nervous system (CNS). Besides
playing a role in the innate immunity, they are also involved in neuronal plasticity and …

Background Abnormal misfolded tau protein is a driving force of neurofibrillary degeneration
in Alzheimer's disease. It has been shown that tau oligomers play a crucial role in the …

The role of microglia and monocyte-derived macrophages in experimental autoimmune
encephalomyelitis pathogenesis has been controversial. To gain insight into their respective …