Methylation of DNA is an essential epigenetic control mechanism in mammals. During
embryonic development, cells are directed toward their future lineages, and DNA …

Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …

Mutations in the cytosine‐5 RNA methyltransferase NSun2 cause microcephaly and other
neurological abnormalities in mice and human. How post‐transcriptional methylation …

Proteins that bind both DNA and RNA typify the ability of a single gene product to perform
multiple functions. Such DNA-and RNA-binding proteins (DRBPs) have unique functional …

The study of epigenetics in plants has a long and rich history, from initial descriptions of non-
Mendelian gene behaviors to seminal discoveries of chromatin-modifying proteins and …

Transfer RNAs (tRNAs) are key for efficient and accurate protein translation. To be fully
active, tRNAs need to be heavily modified post-transcriptionally. Growing evidence indicates …

To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic
pathways of the majority of tRNA modifications include a methylation step (s). Recent studies …

Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their
genomes are typically depleted of CG dinucleotides because of imperfect repair of …

Cellular RNAs can be chemically modified over a hundred different ways. These
modifications were once thought to be static, discrete, and utilized to fine-tune RNA structure …

RNA methylation modifications have been found for decades of years, which occur at
different RNA types of numerous species, and their distribution is species-specific. However …