FoxO transcription factors support oxidative stress resistance in human chondrocytes
Y Akasaki, O Alvarez‐Garcia, M Saito… - Arthritis & …, 2014 - Wiley Online Library
Objective A major signaling pathway that regulates cellular aging is the insulin/insulin‐like
growth factor 1 (IGF‐1)/phosphatidylinositol 3‐kinase (PI3K)/Akt/FoxO transcription factor …
growth factor 1 (IGF‐1)/phosphatidylinositol 3‐kinase (PI3K)/Akt/FoxO transcription factor …
Simultaneous regeneration of full-thickness cartilage and subchondral bone defects in vivo using a three-dimensional scaffold-free autologous construct derived from …
K Ishihara, K Nakayama, S Akieda, S Matsuda… - Journal of orthopaedic …, 2014 - Springer
Background In recent years, several methods have been developed for repairing full-
thickness cartilage defects by tissue engineering using mesenchymal stem cells. Most of …
thickness cartilage defects by tissue engineering using mesenchymal stem cells. Most of …
Advances of human bone marrow-derived mesenchymal stem cells in the treatment of cartilage defects: a systematic review
K Gopal, HA Amirhamed… - Experimental Biology and …, 2014 - journals.sagepub.com
Mesenchymal stem cell (MSC)-based therapies represent a new option for treating
damaged cartilage. However, the outcomes following its clinical application have seldom …
damaged cartilage. However, the outcomes following its clinical application have seldom …
In vitro lifespan and senescence mechanisms of human nucleus pulposus chondrocytes
SW Jeong, JS Lee, KW Kim - The Spine Journal, 2014 - Elsevier
Background context Our previous in vivo study demonstrated that human nucleus pulposus
chondrocytes (NPCs) in aging discs exhibited characteristic senescent features such as an …
chondrocytes (NPCs) in aging discs exhibited characteristic senescent features such as an …
Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three …
Culture conditions that preserve a stable chondrocyte phenotype are desirable in cell-based
cartilage repair to maximize efficacy and clinical outcome. This study investigates whether …
cartilage repair to maximize efficacy and clinical outcome. This study investigates whether …
The effect of resveratrol on normal and osteoarthritic chondrocyte metabolism
HJ Kim, HJ Braun, JL Dragoo - Bone & joint research, 2014 - boneandjoint.org.uk
Background Resveratrol is a polyphenolic compound commonly found in the skins of red
grapes. Sirtuin 1 (SIRT1) is a human gene that is activated by resveratrol and has been …
grapes. Sirtuin 1 (SIRT1) is a human gene that is activated by resveratrol and has been …
Telomerase activity in articular chondrocytes is lost after puberty
B Wilson, KD Novakofski, RS Donocoff… - Cartilage, 2014 - journals.sagepub.com
Objective: Telomere length and telomerase activity are important indicators of cellular
senescence and replicative ability. Loss of telomerase is associated with ageing and the …
senescence and replicative ability. Loss of telomerase is associated with ageing and the …