Epidemiologic and molecular prognostic review of glioblastoma
Glioblastoma multiforme (GBM) is the most common and aggressive primary central nervous
system malignancy with a median survival of 15 months. The average incidence rate of GBM …
system malignancy with a median survival of 15 months. The average incidence rate of GBM …
The epidemiology of glioma in adults: a “state of the science” review
QT Ostrom, L Bauchet, FG Davis, I Deltour… - Neuro …, 2014 - academic.oup.com
Gliomas are the most common primary intracranial tumor, representing 81% of malignant
brain tumors. Although relatively rare, they cause significant mortality and morbidity …
brain tumors. Although relatively rare, they cause significant mortality and morbidity …
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Human cancers are complex ecosystems composed of cells with distinct phenotypes,
genotypes, and epigenetic states, but current models do not adequately reflect tumor …
genotypes, and epigenetic states, but current models do not adequately reflect tumor …
Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised …
W Taal, HM Oosterkamp, AME Walenkamp… - The lancet …, 2014 - thelancet.com
Background Treatment options for recurrent glioblastoma are scarce, with second-line
chemotherapy showing only modest activity against the tumour. Despite the absence of well …
chemotherapy showing only modest activity against the tumour. Despite the absence of well …
Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance
H Easwaran, HC Tsai, SB Baylin - Molecular cell, 2014 - cell.com
The existence of subpopulations of cells in cancers with increased tumor-initiating capacities
and self-renewal potential, often termed" cancer stem cells," is a much discussed and key …
and self-renewal potential, often termed" cancer stem cells," is a much discussed and key …
MGMT testing—the challenges for biomarker-based glioma treatment
Many patients with malignant gliomas do not respond to alkylating agent chemotherapy.
Alkylator resistance of glioma cells is mainly mediated by the DNA repair enzyme O 6 …
Alkylator resistance of glioma cells is mainly mediated by the DNA repair enzyme O 6 …
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
Ependymomas are common childhood brain tumours that occur throughout the nervous
system, but are most common in the paediatric hindbrain. Current standard therapy …
system, but are most common in the paediatric hindbrain. Current standard therapy …
Paediatric and adult glioblastoma: multiform (epi) genomic culprits emerge
We have extended our understanding of the molecular biology that underlies adult
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma
To understand the relationships between the non-GCIMP glioblastoma (GBM) subgroups,
we performed mathematical modeling to predict the temporal sequence of driver events …
we performed mathematical modeling to predict the temporal sequence of driver events …
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers
DA Russler-Germain, DH Spencer, MA Young… - Cancer cell, 2014 - cell.com
Somatic mutations in DNMT3A, which encodes a de novo DNA methyltransferase, are found
in∼ 30% of normal karyotype acute myeloid leukemia (AML) cases. Most mutations are …
in∼ 30% of normal karyotype acute myeloid leukemia (AML) cases. Most mutations are …