Diagnosis and classification of the antiphospholipid syndrome

JA Gómez-Puerta, R Cervera - Journal of autoimmunity, 2014 - Elsevier
The antiphospholipid syndrome (APS) is defined by the occurrence of venous and arterial
thromboses, often multiple, and recurrent fetal losses, frequently accompanied by a …

Efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies: an international and collaborative meta-analysis

L Arnaud, A Mathian, A Ruffatti, D Erkan… - Autoimmunity …, 2014 - Elsevier
We performed a meta-analysis to determine whether aspirin has a significant protective
effect on risk of first thrombosis among patients with antiphospholipid antibodies (aPL+) …

Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation

Y Omatsu, M Seike, T Sugiyama, T Kume, T Nagasawa - Nature, 2014 - nature.com
Haematopoietic stem and progenitor cells are maintained by special microenvironments
known as niches in bone marrow,,,,,. Many studies have identified diverse candidate cells …

Antiphospholipid syndrome in 2014: more clinical manifestations, novel pathogenic players and emerging biomarkers

PL Meroni, CB Chighizola, F Rovelli… - Arthritis research & …, 2014 - Springer
The clinical spectrum of the anti-phospholipid syndrome (APS) is not limited to vascular
thrombosis or miscarriages but includes additional manifestations that cannot be explained …

Obstetric antiphospholipid syndrome: a recent classification for an old defined disorder

S D'Ippolito, PL Meroni, T Koike, M Veglia… - Autoimmunity …, 2014 - Elsevier
Obstetric antiphospholipid syndrome (APS) is now being recognized as a distinct entity from
vascular APS. Pregnancy morbidity includes> 3 consecutive and spontaneous early …

Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations

X Kim-Howard, C Sun, JE Molineros… - Human molecular …, 2014 - academic.oup.com
Recent reports have associated NCF2, encoding a core component of the multi-protein
NADPH oxidase (NADPHO), with systemic lupus erythematosus (SLE) susceptibility in …

Risk factors for arterial thrombosis in antiphospholipid syndrome

A Matyja-Bednarczyk, J Swadźba, T Iwaniec… - Thrombosis research, 2014 - Elsevier
Introduction Antiphospholipid syndrome (APS) is associated with the risk of both arterial and
venous thrombosis. However, it is not known which factors might determine the location of …

Role of Toll‐like receptors 2 and 4 in mediating endothelial dysfunction and arterial remodeling in primary arterial antiphospholipid syndrome

Y Benhamou, J Bellien, G Armengol… - Arthritis & …, 2014 - Wiley Online Library
Objective To assess the role of Toll‐like receptors (TLRs) in antiphospholipid antibody (aPL)–
mediated vascular abnormalities in patients with primary arterial antiphospholipid syndrome …

The role of TLR 4 in pathophysiology of antiphospholipid syndrome‐associated thrombosis and pregnancy morbidity

H Xie, L Sheng, H Zhou, J Yan - British journal of haematology, 2014 - Wiley Online Library
The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the
clinical features of recurrent thrombosis in the venous or arterial circulation and fetal losses …

Management of recurrent thrombosis in antiphospholipid syndrome

C Nalli, L Andreoli, C Casu, A Tincani - Current rheumatology reports, 2014 - Springer
One of the challenges of managing patients with antiphospholipid syndrome is the
prevention of rethrombosis (secondary prophylaxis). Risk stratification, ie traditional …