Obesity and neuroinflammation: a pathway to cognitive impairment

AA Miller, SJ Spencer - Brain, behavior, and immunity, 2014 - Elsevier
Obesity is a growing problem worldwide and is associated with a range of comorbidities,
including cognitive dysfunction. In this review we will address the evidence that obesity and …

Environment and brain plasticity: towards an endogenous pharmacotherapy

A Sale, N Berardi, L Maffei - Physiological reviews, 2014 - journals.physiology.org
Brain plasticity refers to the remarkable property of cerebral neurons to change their
structure and function in response to experience, a fundamental theoretical theme in the …

Stress, glucocorticoid receptors, and adult neurogenesis: a balance between excitation and inhibition?

DJ Saaltink, E Vreugdenhil - Cellular and Molecular Life Sciences, 2014 - Springer
Adult neurogenesis, the birth of new neurons in the mature brain, has attracted considerable
attention in the last decade. One of the earliest identified and most profound factors that …

Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: how important is BDNF?

A Markham, R Bains, P Franklin… - British journal of …, 2014 - Wiley Online Library
The brain is at the very limit of its energy supply and has evolved specific means of adapting
function to energy supply, of which mitochondria form a crucial link. Neurotrophic and …

Voluntary wheel running, but not a diet containing (−)-epigallocatechin-3-gallate and β-alanine, improves learning, memory and hippocampal neurogenesis in aged …

TE Gibbons, BD Pence, G Petr, JM Ossyra… - Behavioural brain …, 2014 - Elsevier
Aging is associated with impaired learning and memory accompanied by reductions in adult
hippocampal neurogenesis and brain expression of neurotrophic factors among other …

The impact of surgery and anesthesia on post-operative cognitive decline and Alzheimer's disease development: biomarkers and preventive strategies

AK Kapila, HR Watts, T Wang… - Journal of Alzheimer's …, 2014 - content.iospress.com
Alzheimer's disease (AD) is a major social and clinical burden in the elderly, affecting 5% of
people aged over 65 and 20% aged over 80. Despite improved management, a cure has not …

Six weeks of voluntary wheel running modulates inflammatory protein (MCP-1, IL-6, and IL-10) and DAMP (Hsp72) responses to acute stress in white adipose tissue of …

KJ Speaker, SS Cox, MM Paton, A Serebrakian… - Brain, behavior, and …, 2014 - Elsevier
To prime local tissues for dealing with potential infection or injury, exposure to an acute,
intense stressor evokes increases in circulating and local tissue inflammatory proteins …

Differential cortical neurotrophin and cytogenetic adaptation after voluntary exercise in normal and amnestic rats

JM Hall, RP Vetreno, LM Savage - Neuroscience, 2014 - Elsevier
Voluntary exercise (VEx) has profound effects on neural and behavioral plasticity, including
recovery of CNS trauma and disease. However, the unique regional cortical adaption to VEx …

Swimming improves the emotional memory deficit by scopolamine via mu opioid receptors

M Nasehi, M Nasehi, F Rahmani-Nia, B Mirzaei… - Physiology & …, 2014 - Elsevier
Aims The aim of the present study was to investigate the effect of swimming exercise on
elevated plus-maze (EPM)-associated memory deficit induced by intra-CA1 injection of …

Low-grade inflammation disrupts structural plasticity in the human brain

C Szabó, O Kelemen, S Kéri - Neuroscience, 2014 - Elsevier
Increased low-grade inflammation is thought to be associated with several neuropsychiatric
disorders characterized by decreased neuronal plasticity. The purpose of the present study …