[HTML][HTML] The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives
Ten years ago we first proposed the Alzheimer's disease (AD) mitochondrial cascade
hypothesis. This hypothesis maintains that gene inheritance defines an individual's baseline …
hypothesis. This hypothesis maintains that gene inheritance defines an individual's baseline …
Genetics of Alzheimer's disease
V Chouraki, S Seshadri - Advances in genetics, 2014 - Elsevier
Alzheimer's disease (AD) represents the main form of dementia, and is a major public health
problem. Despite intensive research efforts, current treatments have only marginal …
problem. Despite intensive research efforts, current treatments have only marginal …
Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers
Abstract The Genetics Core of the Alzheimer's Disease Neuroimaging Initiative (ADNI),
formally established in 2009, aims to provide resources and facilitate research related to …
formally established in 2009, aims to provide resources and facilitate research related to …
A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing
Cognitive decline is a feared aspect of growing old. It is a major contributor to lower quality
of life and loss of independence in old age. We investigated the genetic contribution to …
of life and loss of independence in old age. We investigated the genetic contribution to …
Atherosclerosis and Alzheimer-diseases with a common cause? Inflammation, oxysterols, vasculature
R Lathe, A Sapronova, Y Kotelevtsev - BMC geriatrics, 2014 - Springer
Background Aging is accompanied by increasing vulnerability to pathologies such as
atherosclerosis (ATH) and Alzheimer disease (AD). Are these different pathologies, or …
atherosclerosis (ATH) and Alzheimer disease (AD). Are these different pathologies, or …
An empirically derived composite cognitive test score with improved power to track and evaluate treatments for preclinical Alzheimer's disease
Background There is growing interest in the evaluation of preclinical Alzheimer's disease
(AD) treatments. As a result, there is a need to identify a cognitive composite that is sensitive …
(AD) treatments. As a result, there is a need to identify a cognitive composite that is sensitive …
[HTML][HTML] The broad impact of TOM40 on neurodegenerative diseases in aging
WK Gottschalk, MW Lutz, YT He… - Journal of Parkinson's …, 2014 - ncbi.nlm.nih.gov
Mitochondrial dysfunction is an important factor in the pathogenesis of age-related diseases,
including neurodegenerative diseases like Alzheimer's and Parkinson's spectrum disorders …
including neurodegenerative diseases like Alzheimer's and Parkinson's spectrum disorders …
The Alzheimer's prevention initiative composite cognitive test score: sample size estimates for the evaluation of preclinical Alzheimer's disease treatments in presenilin …
N Ayutyanont, JBS Langbaum, SB Hendrix… - The Journal of clinical …, 2014 - psychiatrist.com
Objective: To identify a cognitive composite that is sensitive to tracking preclinical
Alzheimer's disease decline to be used as a primary end point in treatment trials. Method …
Alzheimer's disease decline to be used as a primary end point in treatment trials. Method …
The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes
Background We investigated the genomic region spanning the Translocase of the Outer
Mitochondrial Membrane 40-kD (TOMM40) and Apolipoprotein E (APOE) genes, that has …
Mitochondrial Membrane 40-kD (TOMM40) and Apolipoprotein E (APOE) genes, that has …
[HTML][HTML] Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936
Apolipoprotein E (APOE) ε genotype has previously been significantly associated with
cognitive, brain imaging, and Alzheimer's disease-related phenotypes (eg, age of onset). In …
cognitive, brain imaging, and Alzheimer's disease-related phenotypes (eg, age of onset). In …