A census of human RNA-binding proteins
Post-transcriptional gene regulation (PTGR) concerns processes involved in the maturation,
transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins …
transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins …
Context-dependent control of alternative splicing by RNA-binding proteins
XD Fu, M Ares Jr - Nature Reviews Genetics, 2014 - nature.com
Sequence-specific RNA-binding proteins (RBPs) bind to pre-mRNA to control alternative
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …
[HTML][HTML] Determination and inference of eukaryotic transcription factor sequence specificity
Transcription factor (TF) DNA sequence preferences direct their regulatory activity, but are
currently known for only∼ 1% of eukaryotic TFs. Broadly sampling DNA-binding domain …
currently known for only∼ 1% of eukaryotic TFs. Broadly sampling DNA-binding domain …
[HTML][HTML] Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli
K Imamura, N Imamachi, G Akizuki, M Kumakura… - Molecular cell, 2014 - cell.com
Although thousands of long noncoding RNAs (lncRNAs) are localized in the nucleus, only a
few dozen have been functionally characterized. Here we show that nuclear enriched …
few dozen have been functionally characterized. Here we show that nuclear enriched …
[HTML][HTML] Synonymous mutations frequently act as driver mutations in human cancers
Synonymous mutations change the sequence of a gene without directly altering the
sequence of the encoded protein. Here, we present evidence that these" silent" mutations …
sequence of the encoded protein. Here, we present evidence that these" silent" mutations …
RBPmap: a web server for mapping binding sites of RNA-binding proteins
Regulation of gene expression is executed in many cases by RNA-binding proteins (RBPs)
that bind to mRNAs as well as to non-coding RNAs. RBPs recognize their RNA target via …
that bind to mRNAs as well as to non-coding RNAs. RBPs recognize their RNA target via …
Enhancer RNAs and regulated transcriptional programs
A large portion of the human genome is transcribed into RNAs without known protein-coding
functions, far outnumbering coding transcription units. Extensive studies of long noncoding …
functions, far outnumbering coding transcription units. Extensive studies of long noncoding …
The structure, function and evolution of proteins that bind DNA and RNA
WH Hudson, EA Ortlund - Nature reviews Molecular cell biology, 2014 - nature.com
Proteins that bind both DNA and RNA typify the ability of a single gene product to perform
multiple functions. Such DNA-and RNA-binding proteins (DRBPs) have unique functional …
multiple functions. Such DNA-and RNA-binding proteins (DRBPs) have unique functional …
[HTML][HTML] RNA Bind-n-Seq: quantitative assessment of the sequence and structural binding specificity of RNA binding proteins
N Lambert, A Robertson, M Jangi, S McGeary… - Molecular cell, 2014 - cell.com
Specific protein-RNA interactions guide posttranscriptional gene regulation. Here, we
describe RNA Bind-n-Seq (RBNS), a method that comprehensively characterizes sequence …
describe RNA Bind-n-Seq (RBNS), a method that comprehensively characterizes sequence …
[HTML][HTML] HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism
The RNA binding proteins Rbfox1/2/3 regulate alternative splicing in the nervous system,
and disruption of Rbfox1 has been implicated in autism. However, comprehensive …
and disruption of Rbfox1 has been implicated in autism. However, comprehensive …