Nuclear mechanics in cancer
C Denais, J Lammerding - Cancer biology and the nuclear envelope …, 2014 - Springer
Despite decades of research, cancer metastasis remains an incompletely understood
process that is as complex as it is devastating. In recent years, there has been an increasing …
process that is as complex as it is devastating. In recent years, there has been an increasing …
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease
The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of proteins within
the inner and the outer nuclear membranes, connects the nuclear lamina to the …
the inner and the outer nuclear membranes, connects the nuclear lamina to the …
Muscular Dystrophy-Associated SUN1 and SUN2 Variants Disrupt Nuclear-Cytoskeletal Connections and Myonuclear Organization
P Meinke, E Mattioli, F Haque, S Antoku… - PLoS …, 2014 - journals.plos.org
Proteins of the nuclear envelope (NE) are associated with a range of inherited disorders,
most commonly involving muscular dystrophy and cardiomyopathy, as exemplified by Emery …
most commonly involving muscular dystrophy and cardiomyopathy, as exemplified by Emery …
Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical …
I Banerjee, J Zhang, T Moore-Morris, E Pfeiffer… - PLoS …, 2014 - journals.plos.org
Recent interest has focused on the importance of the nucleus and associated
nucleoskeleton in regulating changes in cardiac gene expression in response to …
nucleoskeleton in regulating changes in cardiac gene expression in response to …
Emerin in health and disease
AJ Koch, JM Holaska - Seminars in cell & developmental biology, 2014 - Elsevier
Emery-Dreifuss muscular dystrophy (EDMD) is caused by mutations in the genes encoding
emerin, lamins A and C and FHL1. Additional EDMD-like syndromes are caused by …
emerin, lamins A and C and FHL1. Additional EDMD-like syndromes are caused by …
Nesprins in health and disease
S Cartwright, I Karakesisoglou - Seminars in cell & developmental biology, 2014 - Elsevier
LINC (Linker of Nucleoskeleton and Cytoskeleton) complex is an evolutionary conserved
structure that spans the entire nuclear envelope (NE), and integrates the nuclear interior with …
structure that spans the entire nuclear envelope (NE), and integrates the nuclear interior with …
Nesprins: tissue-specific expression of epsilon and other short isoforms
Nesprin-1-giant and nesprin-2-giant regulate nuclear positioning by the interaction of their C-
terminal KASH domains with nuclear membrane SUN proteins and their N-terminal calponin …
terminal KASH domains with nuclear membrane SUN proteins and their N-terminal calponin …
LINC complex proteins in development and disease
HF Horn - Current topics in developmental biology, 2014 - Elsevier
The LINC complex spans the nuclear envelope and plays critical roles in coordinating
nuclear and cytoplasmic activities and in organizing nuclear and cytoskeletal features. LINC …
nuclear and cytoplasmic activities and in organizing nuclear and cytoskeletal features. LINC …
Striated muscle laminopathies
Lamins A and C, encoded by LMNA, are constituent of the nuclear lamina, a meshwork of
proteins underneath the nuclear envelope first described as scaffolding proteins of the …
proteins underneath the nuclear envelope first described as scaffolding proteins of the …
Mammalian microtubule P-body dynamics are mediated by nesprin-1
D Rajgor, JA Mellad, D Soong, JB Rattner… - Journal of Cell …, 2014 - rupress.org
Nesprins are a multi-isomeric family of spectrin-repeat (SR) proteins, predominantly known
as nuclear envelope scaffolds. However, isoforms that function beyond the nuclear envelope …
as nuclear envelope scaffolds. However, isoforms that function beyond the nuclear envelope …