Significance: The molecular machinery regulating autophagy has started becoming
elucidated, and a number of studies have undertaken the task to determine the role of …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential component of cellular
defense against a vast variety of endogenous and exogenous insults, including oxidative …

Oxidative stress is a common hallmark of neuronal cell death associated with
neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, as well as …

Significance: Heme degradation, which was described more than 30 years ago, is still very
actively explored with many novel discoveries on its role in various disease models every …

Abstract Significance: Heme oxygenase-1 (HMOX1) plays a critical role in the protection of
cells, and the inducible enzyme is implicated in a spectrum of human diseases. The …

Fluorouracil (5-FU) is a widely used anticancer drug for the treatment of colorectal cancer
(CRC). However, resistance to 5-FU often prevents the success of chemotherapy. Nuclear …

The inducible form of Heme Oxygenase-1 (HO-1), a major endoplasmic reticulum (ER)
associated heme protein, is known to play important roles in protection against oxidative and …

Abstract Background Heme oxygenase-1 (HO-1) and its major product carbon monoxide
(CO) are known to be involved in the development and progression of many tumors. The …

Prolonged endoplasmic reticulum (ER) stress causes apoptosis and is associated with heart
failure. Whether CYP2J2 and its arachidonic acid metabolites [epoxyeicosatrienoic acids …

Abstract Significance: Heme oxygenases (HO-1 and HO-2) catalyze the degradation of the
pro-oxidant heme into carbon monoxide (CO), iron, and biliverdin, which is subsequently …