Multiple endocrine neoplasia (MEN) is characterized by the occurrence of tumors involving
two or more endocrine glands within a single patient. Four major forms of MEN, which are …

Menin is an essential co-factor of oncogenic MLL fusion proteins and the menin–MLL
interaction is critical for development of acute leukemia in vivo. Targeting the menin–MLL …

摘要胰高血糖素样肽‐1 (Glucagon‐like peptide‐1, GLP‐1) 是小肠在进食后分泌的主要的肠促
胰岛素激素, 其主要生物学功能是促进胰岛β 细胞分泌胰岛素. GLP‐1 通过与G‐蛋白偶联受体(G …

Mutations of the multiple endocrine neoplasia type 1 (MEN1) gene lead to loss of function of
its protein product menin. In keeping with its tumor suppressor function in endocrine tissues …

The identification of the multiple endocrine neoplasia type 1 (MEN1) gene in 1997 has
shown that germline heterozygous mutations in the MEN1 gene located on chromosome …

Menin, the product of the MEN1 gene, functions as a tumor suppressor and was first
identified in 1997 due to its causative role in the endocrine tumor disorder multiple …

The last decades have elucidated the genetic basis of pheochromocytoma (PC) and
paraganglioma (PGL)(PCPGL)-associated hereditary syndromes. However, the history of …

Multiple endocrine neoplasia type 1 (MEN1) is a cancer predisposition syndrome that
includes a combination of endocrine and non‑endocrine tumors. The present study reports a …

Multiple endocrine neoplasia type I (MEN1) is an inherited syndrome that includes
susceptibility to pancreatic islet hyperplasia. This syndrome results from mutations in the …

Neuroendocrine tumors (NET) of the pancreas are uncommon neoplasms that arise from the
pancreatic islet cells. The clinical presentation of specific tumors is characterized by unique …