Proteins are continuously affected by various intrinsic and extrinsic factors. Damaged
proteins influence several intracellular pathways and result in different disorders and …

Background The maintenance of cell metabolism and homeostasis is a fundamental
characteristic of living organisms. In eukaryotes, mitochondria are the cornerstone of these …

Pancreatic β-cell dysfunction and death are central in the pathogenesis of type 2 diabetes
(T2D). Saturated fatty acids cause β-cell failure and contribute to diabetes development in …

We generated mice deficient in Lon protease (LONP1), a major enzyme of the mitochondrial
quality control machinery. Homozygous deletion of Lonp1 causes early embryonic lethality …

Loss-of-function mutations in PINK1, which encodes a mitochondrially targeted
serine/threonine kinase, result in an early-onset heritable form of Parkinson's disease …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive loss of upper and lower motor neurons. Although the etiology remains unclear …

Although mitochondrial function is often altered in cancer, it remains essential for tumor
viability. Tight control of protein homeostasis is required for the maintenance of …

Carbonylation is an irreversible oxidative modification of proteins induced by reactive
oxygen species (ROS) and reactive nitrogen species (RNS) or by-products of oxidative …

ATP-dependent Lon protease within mitochondrial matrix contributes to the degradation of
abnormal proteins. The oxidative or hypoxic stress which represents the stress phenotype of …

Various molecular and cellular pathways are active in eukaryotes to control the quality and
integrity of mitochondria. These pathways are involved in keeping a 'healthy'population of …