Gene-based therapy is the intentional modulation of gene expression in specific cells to treat
pathological conditions. This modulation is accomplished by introducing exogenous nucleic …

MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that have crucial
roles in regulating gene expression. Increasing evidence supports a role for miRNAs in …

Many chemotherapeutics used for cancer treatments encounter issues during delivery to
tumors in vivo and may have high levels of systemic toxicity due to their nonspecific …

Over the past three decades DNA has emerged as an exceptional molecular building block
for nanoconstruction due to its predictable conformation and programmable intra-and …

DNA is typically impermeable to the plasma membrane due to its polyanionic nature.
Interestingly, several different DNA nanostructures can be readily taken up by cells in the …

DNA nanotechnology enables engineering of molecular-scale devices with exquisite control
over geometry and site-specific functionalization. This capability promises compelling …

A bioinspired cocoon-like anticancer drug delivery system consisting of a
deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl) embedded with an acid …

There has been tremendous interest in constructing nanostructures by exploiting the
unparalleled ability of DNA molecules in self-assembly. We have seen the appearance of …

RNA interference (RNAi) therapy is a rapidly emerging platform for personalized cancer
treatment. Recent advances in small interfering RNA delivery and target selection provide …

Conspectus Nanotechnology's central goal involves the direct control of matter at the
molecular nanometer scale to build nanofactories, nanomachines, and other devices for …