The complement system in systemic lupus erythematosus: an update

J Leffler, AA Bengtsson, AM Blom - Annals of the rheumatic diseases, 2014 - ard.bmj.com
The complement system plays a major role in the autoimmune disease, systemic lupus
erythematosus (SLE). However, the role of complement in SLE is complex since it may both …

Optimizing outcome in SLE: treating-to-target and definition of treatment goals

A Doria, M Gatto, M Zen, L Iaccarino, L Punzi - Autoimmunity reviews, 2014 - Elsevier
Patients affected with systemic lupus erythematosus (SLE) display poor-long term prognosis
and increased mortality in respect of general population. This may be due to continuous …

Predictors of maternal and fetal complications in SLE patients: a prospective study

E Borella, A Lojacono, M Gatto, L Andreoli… - Immunologic …, 2014 - Springer
The aim of the study was to evaluate predictors of disease flares during pregnancy and
obstetric and fetal complications in a cohort of systemic lupus erythematosus (SLE) patients …

Impact of race and ethnicity in the course and outcome of systemic lupus erythematosus

LA González, SMA Toloza… - Rheumatic Disease …, 2014 - rheumatic.theclinics.com
Ethnicity is a biological and a social construct, which includes ancestral genes and cultural,
geographic, and socioeconomic characteristics shared by populations. 1, 2 In contrast, race …

Burden of corticosteroid use in patients with systemic lupus erythematosus: results from a Delphi panel

M Petri, B Bechtel, G Dennis, M Shah, T McLaughlin… - Lupus, 2014 - journals.sagepub.com
Corticosteroid-related adverse events (AEs) are commonly reported in systemic lupus
erythematosus (SLE), but are often under-represented in claims data. The most common …

American College of Rheumatology criteria at inception, and accrual over 5 years in the SLICC inception cohort

MB Urowitz, DD Gladman, D Ibañez… - The Journal of …, 2014 - jrheum.org
Objective. To determine the frequency of each American College of Rheumatology (ACR)
criterion met at time of enrollment, and the increase in each of the criteria over 5 years …

Changes in referral, treatment and outcomes in patients with systemic lupus erythematosus in Germany in the 1990s and the 2000s

K Albrecht, D Huscher, J Richter… - Lupus science & …, 2014 - lupus.bmj.com
Objective To evaluate trends in the referral, treatment and outcome of patients with systemic
lupus erythematosus (SLE) in Germany over two decades. Methods From 1993 to 2012,∼ …

Post-marketing experiences with belimumab in the treatment of SLE patients

AD Askanase, J Yazdany… - Rheumatic Disease …, 2014 - rheumatic.theclinics.com
Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple
organ systems and whose hallmark is the production of autoantibodies. 1–3 A diagnosis of …

Longitudinal validation of the brief index of lupus damage

P Katz, L Trupin, S Rush, J Yazdany - Arthritis care & research, 2014 - Wiley Online Library
Objective To provide further validation of the Brief Index of Lupus Damage (BILD), assessing
its sensitivity to change in disease status and ability to predict mortality risk. Methods Data …

Systemic lupus erythematosus: a therapeutic challenge for the XXI century

MF Ugarte-Gil, GS Alarcón - Clinical rheumatology, 2014 - Springer
Despite significant advances in our understanding of the pathogenesis of systemic lupus
erythematosus (SLE), there are only a few drugs approved by the regulatory agencies …