[HTML][HTML] The ubiquitin proteasome system—implications for cell cycle control and the targeted treatment of cancer
Two families of E3 ubiquitin ligases are prominent in cell cycle regulation and mediate the
timely and precise ubiquitin–proteasome-dependent degradation of key cell cycle proteins …
timely and precise ubiquitin–proteasome-dependent degradation of key cell cycle proteins …
The eukaryotic linear motif resource ELM: 10 years and counting
H Dinkel, K Van Roey, S Michael… - Nucleic acids …, 2014 - academic.oup.com
The eukaryotic linear motif (ELM http://elm. eu. org) resource is a hub for collecting,
classifying and curating information about short linear motifs (SLiMs). For> 10 years, this …
classifying and curating information about short linear motifs (SLiMs). For> 10 years, this …
Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle
V Oakes, W Wang, B Harrington, WJ Lee, H Beamish… - Cell cycle, 2014 - Taylor & Francis
Whereas many components regulating the progression from S phase through G2 phase into
mitosis have been identified, the mechanism by which these components control this critical …
mitosis have been identified, the mechanism by which these components control this critical …
Glucose and glutamine metabolism control by APC and SCF during the G1-to-S phase transition of the cell cycle
IO Estévez-García, V Cordoba-Gonzalez… - Journal of physiology …, 2014 - Springer
Recent studies have given us a clue as to how modulations of both metabolic pathways and
cyclins by the ubiquitin system influence cell cycle progression. Among these metabolic …
cyclins by the ubiquitin system influence cell cycle progression. Among these metabolic …
Inhibition of dynamin related protein 1 to promote cell death
W Qian, B Van Houten - US Patent 8,759,097, 2014 - Google Patents
The present invention relates to compositions and methods for reducing cell proliferation
and/or promoting cell death by inhibiting Drp1. It is based, at least in part, on the discoveries …
and/or promoting cell death by inhibiting Drp1. It is based, at least in part, on the discoveries …
Loss of Cdh1 Triggers Premature Senescence in Part via Activation of Both the RB/E2F1 and the CLASPIN/CHK1/P53 Tumor Suppressor Pathways
Senescence is recently characterized as one of the evolutionarily conserved protective
mechanisms against tumor development. Several upstream factors including oxidative …
mechanisms against tumor development. Several upstream factors including oxidative …