At least 10% of adults and nearly all children who receive renal-replacement therapy have
an inherited kidney disease. These patients rarely die when their disease progresses and …

Glomerular diseases developing in the kidney allograft are more often recurrences of the
original disease affecting the native kidneys. However, in an undefined number of cases de …

Podocyte injury and resulting albuminuria are hallmarks of diabetic nephropathy, but
targeted therapies to halt or prevent these complications are currently not available. Here …

Toll-like receptor 4 (TLR4), a component of the innate immune system, is recognized to
promote tubulointerstitial inflammation in overt diabetic nephropathy (DN). However, there is …

Abatacept (cytotoxic T-lymphocyte–associated antigen 4–immunoglobulin fusion protein
[CTLA-4–Ig]) is a costimulatory inhibitor that targets B7-1 (CD80). The present report …

Background Minimal change disease (MCD) is characterized by increased urinary excretion
of CD80, whereas focal segmental glomerulosclerosis (FSGS) is associated with increased …

Inflammation is involved in the development and/or progression of diabetic nephropathy
(DN). Curcumin has been reported for its anti-inflammation activity in DN. However, the …

Albuminuria is both a hallmark and a risk factor for progressive glomerular disease, and
results in increased exposure of podocytes to serum albumin with its associated factors …

Abstract Background Minimal Change Disease (MCD) is associated with CD80 expression
in podocytes and elevated urinary CD80 excretion during active renal disease. We have …

Idiopathic change nephrotic syndrome (INS), the most frequent glomerular disease in
children and young adults, is characterized by heavy proteinuria and a relapsing remitting …