Mechanisms of activation of receptor tyrosine kinases: monomers or dimers
IN Maruyama - Cells, 2014 - mdpi.com
Receptor tyrosine kinases (RTKs) play essential roles in cellular processes, including
metabolism, cell-cycle control, survival, proliferation, motility and differentiation. RTKs are all …
metabolism, cell-cycle control, survival, proliferation, motility and differentiation. RTKs are all …
Nerve growth factor metabolic dysfunction in Alzheimer's disease and Down syndrome
Alzheimer's disease (AD) is a devastating neurodegenerative condition and the most
common type of amnestic dementia in the elderly. Individuals with Down syndrome (DS) are …
common type of amnestic dementia in the elderly. Individuals with Down syndrome (DS) are …
The biological functions and signaling mechanisms of the p75 neurotrophin receptor
BR Kraemer, SO Yoon, BD Carter - Neurotrophic factors, 2014 - Springer
The p75 neurotrophin receptor (p75 NTR) regulates a wide range of cellular functions,
including programmed cell death, axonal growth and degeneration, cell proliferation …
including programmed cell death, axonal growth and degeneration, cell proliferation …
Deciphering proneurotrophin actions
BL Hempstead - Neurotrophic factors, 2014 - Springer
Like most growth factors, neurotrophins are initially synthesized as precursors that are
cleaved to release C-terminal mature forms. The well-characterized mature neurotrophins …
cleaved to release C-terminal mature forms. The well-characterized mature neurotrophins …
Dynamic nature of the p75 neurotrophin receptor in response to injury and disease
R Meeker, K Williams - Journal of neuroimmune pharmacology, 2014 - Springer
Neurotrophins and their respective tropomyosin related kinase (Trk) receptors (TrkA, TrkB,
and TrkC) and the p75 neurotrophin receptor (p75 NTR) play a fundamental role in the …
and TrkC) and the p75 neurotrophin receptor (p75 NTR) play a fundamental role in the …
Role of p75 neurotrophin receptor in stem cell biology: more than just a marker
E Tomellini, C Lagadec, R Polakowska… - Cellular and molecular …, 2014 - Springer
Abstract p75 NTR, the common receptor for both neurotrophins and proneurotrophins, has
been widely studied because of its role in many tissues, including the nervous system. More …
been widely studied because of its role in many tissues, including the nervous system. More …
Neurotrophins in the regulation of cellular survival and death
The neurotrophins play crucial roles regulating survival and apoptosis in the developing and
injured nervous system. The four neurotrophins exert profound and crucial survival effects …
injured nervous system. The four neurotrophins exert profound and crucial survival effects …
A role for the p75 neurotrophin receptor in axonal degeneration and apoptosis induced by oxidative stress
The p75 neurotrophin receptor (p75 NTR) mediates the death of specific populations of
neurons during the development of the nervous system or after cellular injury. The receptor …
neurons during the development of the nervous system or after cellular injury. The receptor …
Molecular mechanisms of cognitive impairment in iron deficiency: alterations in brain-derived neurotrophic factor and insulin-like growth factor expression and function …
Objective The present review examines the relationship between iron deficiency and central
nervous system (CNS) development and cognitive impairment, focusing on the cellular and …
nervous system (CNS) development and cognitive impairment, focusing on the cellular and …
p75NTR, but Not proNGF, Is Upregulated Following Status Epilepticus in Mice
MW VonDran, J LaFrancois, VA Padow… - ASN …, 2014 - journals.sagepub.com
ProNGF and p75NTR are upregulated and induce cell death following status epilepticus
(SE) in rats. However, less is known about the proneurotrophin response to SE in mice, a …
(SE) in rats. However, less is known about the proneurotrophin response to SE in mice, a …