microRNAs in cardiovascular diseases: current knowledge and the road ahead

G Condorelli, MVG Latronico, E Cavarretta - Journal of the American …, 2014 - jacc.org
Over the last few years, the field of microribonucleic acid (miRNA) in cardiovascular biology
and disease has expanded at an incredible pace. miRNAs are themselves part of a larger …

Mechanisms of aortic aneurysm formation: translating preclinical studies into clinical therapies

FM Davis, DL Rateri, A Daugherty - Heart, 2014 - heart.bmj.com
Aneurysms are common in the abdominal and thoracic regions of the aorta. While generally
asymptomatic, progression of aneurysms is associated with the devastating consequences …

[HTML][HTML] miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development

L Maegdefessel, JM Spin, U Raaz, SM Eken… - Nature …, 2014 - nature.com
Identification and treatment of abdominal aortic aneurysm (AAA) remain among the most
prominent challenges in vascular medicine. MicroRNAs (miRNAs) are crucial regulators of …

[HTML][HTML] Fibulin-4 and fibulin-5 in elastogenesis and beyond: Insights from mouse and human studies

CL Papke, H Yanagisawa - Matrix Biology, 2014 - Elsevier
The fibulin family of extracellular matrix/matricellular proteins is composed of long fibulins
(fibulin-1,-2,-6) and short fibulins (fibulin-3,-4,-5,-7) and is involved in protein–protein …

Role of miR-195 in aortic aneurysmal disease

A Zampetaki, R Attia, U Mayr, RSM Gomes… - Circulation …, 2014 - Am Heart Assoc
Rationale: Abdominal aortic aneurysms constitute a degenerative process in the aortic wall.
Both the miR-29 and miR-15 families have been implicated in regulating the vascular …

Emerging role of microRNAs in cardiovascular diseases

S De Rosa, A Curcio, C Indolfi - Circulation Journal, 2014 - jstage.jst.go.jp
568 DE ROSA S et al. ulated in Zmpste24−/− mice, an animal disease model for the
Hutchinson–Gilford progeria. 37 Consistently, members of the miR-29 family showed an …

Prevention of abdominal aortic aneurysm by Anti–MicroRNA-712 or Anti–MicroRNA-205 in angiotensin II–infused mice

CW Kim, S Kumar, DJ Son, IH Jang… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Abdominal aortic aneurysm (AAA) is characterized as a progressive dilation and
degradation of the aortic wall, associated with activation of matrix metalloproteinases …

The emerging role of micro RNA s in cardiovascular disease

L Maegdefessel - Journal of internal medicine, 2014 - Wiley Online Library
Cardiovascular disease remains the most prevalent cause of human morbidity and mortality
in ageing Western societies. Basic and translational scientific efforts have focused on the …

Vascular homeostasis and the concept of mechanobiological stability

CJ Cyron, JD Humphrey - International journal of engineering science, 2014 - Elsevier
Vascular mechanics has been studied in depth since the early 1970s mainly following
classical concepts from continuum mechanics. Yet, an important distinction of blood vessels …

[HTML][HTML] In Vitro and In Vivo Activity of a Novel Locked Nucleic Acid (LNA)-Inhibitor-miR-221 against Multiple Myeloma Cells

MT Di Martino, A Gullà, ME Gallo Cantafio, E Altomare… - PloS one, 2014 - journals.plos.org
Background & Aim The miR-221/222 cluster is upregulated in malignant plasma cells from
multiple myeloma (MM) patients harboring the t (4; 14) translocation. We previously reported …