Epigenetics of discordant monozygotic twins: implications for disease
Monozygotic (MZ) twins share nearly all of their genetic variants and many similar
environments before and after birth. However, they can also show phenotypic discordance …
environments before and after birth. However, they can also show phenotypic discordance …
Viruses as potential pathogenic agents in systemic lupus erythematosus
P Nelson, P Rylance, D Roden, M Trela, N Tugnet - Lupus, 2014 - journals.sagepub.com
Genetic and environmental factors appear to contribute to the pathogenesis of systemic
lupus erythematosus (SLE). Viral infections have been reported to be associated with the …
lupus erythematosus (SLE). Viral infections have been reported to be associated with the …
DNA methylation map of human atherosclerosis
Background—Epigenetic alterations may contribute to the development of atherosclerosis.
In particular, DNA methylation, a reversible and highly regulated DNA modification, could …
In particular, DNA methylation, a reversible and highly regulated DNA modification, could …
DNA methylation profiles in type 1 diabetes twins point to strong epigenetic effects on etiology
M Stefan, W Zhang, E Concepcion, Z Yi, Y Tomer - Journal of autoimmunity, 2014 - Elsevier
Abstract Type 1 diabetes (T1D) shows∼ 40% concordance rate in monozygotic twins (MZ)
suggesting a role for environmental factors and/or epigenetic modifications in the etiology of …
suggesting a role for environmental factors and/or epigenetic modifications in the etiology of …
Epigenetics: relevance and implications for public health
Improved understanding of the multilayer regulation of the human genome has led to a
greater appreciation of environmental, nutritional, and epigenetic risk factors for human …
greater appreciation of environmental, nutritional, and epigenetic risk factors for human …
Lipocalin-2 protein deficiency ameliorates experimental autoimmune encephalomyelitis: the pathogenic role of lipocalin-2 in the central nervous system and …
Lipocalin-2 (LCN2) plays an important role in cellular processes as diverse as cell growth,
migration/invasion, differentiation, and death/survival. Furthermore, recent studies indicate …
migration/invasion, differentiation, and death/survival. Furthermore, recent studies indicate …
Epigenetic epidemiology: promises for public health research
KM Bakulski, MD Fallin - Environmental and molecular …, 2014 - Wiley Online Library
Epigenetic changes underlie developmental and age related biology. Promising
epidemiologic research implicates epigenetics in disease risk and progression, and …
epidemiologic research implicates epigenetics in disease risk and progression, and …
MethylPurify: tumor purity deconvolution and differential methylation detection from single tumor DNA methylomes
We propose a statistical algorithm MethylPurify that uses regions with bisulfite reads
showing discordant methylation levels to infer tumor purity from tumor samples alone …
showing discordant methylation levels to infer tumor purity from tumor samples alone …
Monozygotic twins discordant for recessive dystrophic epidermolysis bullosa phenotype highlight the role of TGF-β signalling in modifying disease severity
T Odorisio, M Di Salvio, A Orecchia… - Human molecular …, 2014 - academic.oup.com
Recessive dystrophic epidermolysis bullosa (RDEB) is a genodermatosis characterized by
fragile skin forming blisters that heal invariably with scars. It is due to mutations in the …
fragile skin forming blisters that heal invariably with scars. It is due to mutations in the …
Epigenetic alterations and microRNA misexpression in cancer and autoimmune diseases: a critical review
Y Saito, H Saito, G Liang, JM Friedman - Clinical reviews in allergy & …, 2014 - Springer
Epigenetic markers such as DNA methylation and histone modifications around promoter
regions modify chromatin structure and regulate expression of downstream genes. In fact …
regions modify chromatin structure and regulate expression of downstream genes. In fact …