Gut microbes and the brain: paradigm shift in neuroscience

EA Mayer, R Knight, SK Mazmanian… - Journal of …, 2014 - Soc Neuroscience
The discovery of the size and complexity of the human microbiome has resulted in an
ongoing reevaluation of many concepts of health and disease, including diseases affecting …

The microbiome in inflammatory bowel disease: current status and the future ahead

AD Kostic, RJ Xavier, D Gevers - Gastroenterology, 2014 - Elsevier
Studies of the roles of microbial communities in the development of inflammatory bowel
disease (IBD) have reached an important milestone. A decade of genome-wide association …

Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease

NW Palm, MR De Zoete, TW Cullen, NA Barry… - Cell, 2014 - cell.com
Specific members of the intestinal microbiota dramatically affect inflammatory bowel disease
(IBD) in mice. In humans, however, identifying bacteria that preferentially affect disease …

The intestinal microbiome in early life: health and disease

MC Arrieta, LT Stiemsma, N Amenyogbe… - Frontiers in …, 2014 - frontiersin.org
Human microbial colonization begins at birth and continues to develop and modulate in
species abundance for about 3 years, until the microbiota becomes adult-like. During the …

[HTML][HTML] Meta-analyses of human gut microbes associated with obesity and IBD

WA Walters, Z Xu, R Knight - FEBS letters, 2014 - Elsevier
Recent studies have linked human gut microbes to obesity and inflammatory bowel disease,
but consistent signals have been difficult to identify. Here we test for indicator taxa and …

Potential of fecal microbiota for early‐stage detection of colorectal cancer

G Zeller, J Tap, AY Voigt, S Sunagawa… - Molecular systems …, 2014 - embopress.org
Several bacterial species have been implicated in the development of colorectal carcinoma
(CRC), but CRC‐associated changes of fecal microbiota and their potential for cancer …

A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics

MS Donia, P Cimermancic, CJ Schulze, LCW Brown… - Cell, 2014 - cell.com
In complex biological systems, small molecules often mediate microbe-microbe and microbe-
host interactions. Using a systematic approach, we identified 3,118 small-molecule …

The Integrative Human Microbiome Project: dynamic analysis of microbiome-host omics profiles during periods of human health and disease

HMP Integrative - Cell host & microbe, 2014 - pubmed.ncbi.nlm.nih.gov
Much has been learned about the diversity and distribution of human-associated microbial
communities, but we still know little about the biology of the microbiome, how it interacts with …

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

Y Haberman, TL Tickle, PJ Dexheimer… - The Journal of …, 2014 - Am Soc Clin Investig
Interactions between the host and gut microbial community likely contribute to Crohn
disease (CD) pathogenesis; however, direct evidence for these interactions at the onset of …

Antibiotics associated with increased risk of new-onset Crohn's disease but not ulcerative colitis: a meta-analysis

R Ungaro, CN Bernstein, R Gearry… - Official journal of the …, 2014 - journals.lww.com
OBJECTIVES: The objective of this study was to perform a meta-analysis investigating
antibiotic exposure as a risk factor for developing inflammatory bowel disease (IBD) …