[HTML][HTML] Childhood B-acute lymphoblastic leukemia: a genetic update
JS Woo, MO Alberti, CA Tirado - Experimental hematology & oncology, 2014 - Springer
In the pediatric population, B-acute lymphoblastic leukemia (B-ALL) is the most prevalent
childhood hematological malignancy, as well as the leading cause of childhood cancer …
childhood hematological malignancy, as well as the leading cause of childhood cancer …
The genomic landscape of acute lymphoblastic leukemia in children and young adults
CG Mullighan - Hematology 2014, the American Society of …, 2014 - ashpublications.org
Our understanding of the genetic basis of childhood acute lymphoblastic leukemia (ALL) has
been greatly advanced by genomic profiling and sequencing studies. These efforts have …
been greatly advanced by genomic profiling and sequencing studies. These efforts have …
[HTML][HTML] Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia
KG Roberts, Y Li, D Payne-Turner… - New England journal …, 2014 - Mass Medical Soc
Background Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is
characterized by a gene-expression profile similar to that of BCR–ABL1–positive ALL …
characterized by a gene-expression profile similar to that of BCR–ABL1–positive ALL …
[HTML][HTML] Outcomes of children with BCR-ABL1–like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease
KG Roberts, D Pei, D Campana… - Journal of Clinical …, 2014 - ncbi.nlm.nih.gov
Purpose BCR-ABL1–like acute lymphoblastic leukemia (ALL) is a recently identified B-cell
ALL (B-ALL) subtype with poor outcome that exhibits a gene expression profile similar to …
ALL (B-ALL) subtype with poor outcome that exhibits a gene expression profile similar to …
Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group
TD Buitenkamp, S Izraeli… - Blood, The Journal …, 2014 - ashpublications.org
Children with Down syndrome (DS) have an increased risk of B-cell precursor (BCP) acute
lymphoblastic leukemia (ALL). The prognostic factors and outcome of DS-ALL patients …
lymphoblastic leukemia (ALL). The prognostic factors and outcome of DS-ALL patients …
A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia
Recent genomic studies have provided a refined genetic map of acute lymphoblastic
leukemia (ALL) and increased the number of potential prognostic markers. Therefore, we …
leukemia (ALL) and increased the number of potential prognostic markers. Therefore, we …
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation
Down syndrome confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (B-
ALL), and polysomy 21 is the most frequent somatic aneuploidy among all B-ALLs. Yet the …
ALL), and polysomy 21 is the most frequent somatic aneuploidy among all B-ALLs. Yet the …
TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling
Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role
in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP …
in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP …
Haematopoietic development and leukaemia in D own syndrome
I Roberts, S Izraeli - British journal of haematology, 2014 - Wiley Online Library
Children with constitutional trisomy 21 (cT 21, D own S yndrome, DS) are at a higher risk for
both myeloid and B‐lymphoid leukaemias. The myeloid leukaemias are often preceded by a …
both myeloid and B‐lymphoid leukaemias. The myeloid leukaemias are often preceded by a …
[PDF][PDF] IGH@ translocations are prevalent in teenagers and young adults with acute lymphoblastic leukemia and are associated with a poor outcome
IGH@ Translocations Are Prevalent in Teenagers and Young Adults With Acute Lymphoblastic
Leukemia and Are Associated With a Poor Page 1 IGH@ Translocations Are Prevalent in …
Leukemia and Are Associated With a Poor Page 1 IGH@ Translocations Are Prevalent in …