About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

Cardiomyocytes rely on a highly specialized subcellular architecture to maintain normal
cardiac function. In a little over a decade, junctophilin-2 (JPH2) has become recognized as a …

Background—Pitx2 is the homeobox gene located in proximity to the human 4q25 familial
atrial fibrillation (AF) locus. When deleted in the mouse germline, Pitx2 haploinsufficiency …

Atrial fibrillation is associated with substantial morbidity and mortality rates. The incompletely
understood pathogenesis of this cardiac dysrhythmia makes it difficult to improve …

Atrial fibrillation (AF) is the most frequently encountered clinical arrhythmia and is associated
with increased morbidity and mortality. Ectopic activity and reentry are considered major …

Atrial fibrillation (AF) is the most common cardiac arrhythmia, but our knowledge of the
arrhythmogenic substrate is incomplete. Alternans, the beat-to-beat alternation in the shape …

Objective: Recently, we reported that low-dose landiolol (1.5 µg· kg-1· min-1), an ultra-short-
acting β-blocker, safely decreased the heart rate (HR) in patients with acute decompensated …

Atrial fibrillation is a complex arrhythmia with multiple possible mechanisms. A lot of
experimental and clinical studies have shed light on the pathophysiological mechanisms of …

Atrial fibrillation is the most common clinically significant cardiac arrhythmia, increasing the
risk of stroke, heart failure and morbidity and mortality. Current therapies, including rate …

Atrial fibrillation (AF) is the most common cardiac arrhythmia, contributing to increased
morbidity and reduced survival through its associations with stroke and heart failure. AF …