The developing brain is talkative but its language is not that of the adult. Most if not all
voltage and transmitter-gated ionic currents follow a developmental sequence and network …

Seizures are a common manifestation of acute neurologic insults in neonates and are often
resistant to the standard antiepileptic drugs that are efficacious in children and adults. The …

Neuronal intracellular chloride concentration [Cl–] i is an important determinant of γ-
aminobutyric acid type A (GABAA) receptor (GABAAR)–mediated inhibition and cytoplasmic …

Chloride homeostasis has a pivotal role in controlling neuronal excitability in the adult brain
and during development. The intracellular concentration of chloride is regulated by the …

It is now a well‐accepted view that cation‐driven Cl− transporters in neurons are involved in
determining the intracellular Cl− concentration. In the present review, we propose that …

Background Stroke is the second most common cause of seizures in term neonates and is
associated with abnormal long-term neurodevelopmental outcome in some cases. Objective …

Cajal-Retzius cells orchestrate the development of cortical circuits by secreting the
glycoprotein reelin. However, their computational functions are still unknown. In fact, the …

Response to Comments on “Local impermeant anions establish the neuronal chloride
concentration” | Science news careers commentary Journals Science Science brought to you …

Background Barbiturates and benzodiazepines are the first-line anticonvulsants for neonatal
seizures. However, in immature brains, those drugs may lead to paradoxical neuronal …

The brain is organized into neuronal networks, many of which have a specific task and
function. Neuronal networks are further modified through cross-interactions among them but …