Epigenetic epidemiology includes the study of variation in epigenetic traits and the risk of
disease in populations. Its application to the field of cancer has provided insight into how …

Despite a decline in the overall incidence of gastric cancer (GC), the disease remains the
second most common cause of cancer-related death worldwide and is thus a significant …

Background Ductal carcinoma in situ (DCIS) of the breast is a precursor of invasive breast
carcinoma. DNA methylation alterations are thought to be an early event in progression of …

The changes in DNA methylation status in cancer cells are characterized by
hypermethylation of promoter CpG islands and diffuse genomic hypomethylation. Alu and …

Breast cancers (BCs) of the luminal B subtype are estrogen receptor-positive (ER+), highly
proliferative, resistant to standard therapies and have a poor prognosis. To better …

Introduction Breast cancer is a heterogeneous disease, with several intrinsic subtypes
differing by hormone receptor (HR) status, molecular profiles, and prognosis. However, the …

Epigenetic modifications introduce an additional layer of regulation that drastically expands
the instructional capability of the human genome. The regulatory consequences of DNA …

Objectives Accumulating evidence indicates that aberrant DNA methylation is closely related
to oral carcinogenesis, and it has been shown that methylation changes might be used as …

Aberrant epigenetics is a hallmark of cancer, and endocrine-related tumors are no
exception. Recent research has been identifying an ever-growing number of epigenetic …

Breast cancer is a highly heterogeneous disease that is characterized by genetic and
epigenetic aberrations; however, our knowledge of epigenetic alterations of breast cancer …