Allergic sensitization is the outcome of a complex interplay between the allergen and the
host in a given environmental context. The first barrier encountered by an allergen on its way …

Cystic fibrosis (CF) remains the most common fatal hereditary lung disease. The discovery of
the cystic fibrosis transmembrane conductance regulator (CFTR) gene 25 years ago set the …

Despite remarkable progress following the identification of the causing gene, the final
outcome of cystic fibrosis (CF) remains determined mainly by the progressive reduction of …

Rationale: The mechanisms underlying cystic fibrosis (CF) lung disease pathogenesis are
unknown. Objectives: To establish mechanisms linking anion transport with the functional …

Bdellovibrio bacteriovorus is a predator bacterial species found in the environment and
within the human gut, able to attack Gram-negative prey. Cystic fibrosis (CF) is a genetic …

Obstructive lung diseases in the lower airways are a leading health concern worldwide. To
improve our understanding of the pathophysiology of lower airways, we studied airflow …

Rationale The cystic fibrosis transmembrane conductance regulator (CFTR) and Calcium-
activated Chloride Conductance (CaCC) each play critical roles in maintaining normal …

Why is a healthy person protected from Pseudomonas aeruginosa infections, while
individuals with cystic fibrosis or damaged epithelium are particularly susceptible to this …

In cystic fibrosis (CF), the airway surface liquid (ASL) height is reduced as a result of
impaired ion transport, which favors bacterial colonization and inflammation of the airway …

Organization of airway epithelium determines ciliary beat direction and coordination for
proper mucociliary clearance. Fluidic shear stresses have the potential to influence ciliary …