Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions
JA Roberts, MH Abdul-Aziz, J Lipman… - The Lancet infectious …, 2014 - thelancet.com
Infections in critically ill patients are associated with persistently poor clinical outcomes.
These patients have severely altered and variable antibiotic pharmacokinetics and are …
These patients have severely altered and variable antibiotic pharmacokinetics and are …
Prolonging β-lactam infusion: a review of the rationale and evidence, and guidance for implementation
SH MacVane, JL Kuti, DP Nicolau - International journal of antimicrobial …, 2014 - Elsevier
Given the sparse antibiotic pipeline and the increasing prevalence of resistant organisms,
efforts should be made to optimise the pharmacodynamic exposure of currently available …
efforts should be made to optimise the pharmacodynamic exposure of currently available …
Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients
Purpose Risk factors for β-lactam antibiotic underdosing in critically ill patients have not
been described in large-scale studies. The objective of this study was to describe …
been described in large-scale studies. The objective of this study was to describe …
How severe is antibiotic pharmacokinetic variability in critically ill patients and what can be done about it?
The pharmacokinetics (PK) of antimicrobial agents administered to critically ill patients
exhibit marked variability. This variability results from pathophysiological changes that occur …
exhibit marked variability. This variability results from pathophysiological changes that occur …
Population pharmacokinetics of imipenem in critically ill patients with suspected ventilator‐associated pneumonia and evaluation of dosage regimens
C Couffignal, O Pajot, C Laouénan… - British Journal of …, 2014 - Wiley Online Library
Aims Significant alterations in the pharmacokinetics (PK) of antimicrobials have been
reported in critically ill patients. We describe PK parameters of imipenem in intensive care …
reported in critically ill patients. We describe PK parameters of imipenem in intensive care …
[HTML][HTML] Challenges and potential solutions–individualised antibiotic dosing at the bedside for critically ill patients: a structured review
JA Roberts, MMHA Aziz, J Lipman… - The Lancet. Infectious …, 2014 - ncbi.nlm.nih.gov
Infections in critically ill patients are associated with persistently poor clinical outcomes.
These patients have severely altered and variable antibiotic pharmacokinetics and are …
These patients have severely altered and variable antibiotic pharmacokinetics and are …
Population pharmacokinetics and dosing simulations of cefuroxime in critically ill patients: non-standard dosing approaches are required to achieve therapeutic …
M Carlier, M Noë, JA Roberts, V Stove… - Journal of …, 2014 - academic.oup.com
Objectives To investigate the population pharmacokinetics of cefuroxime in critically ill
patients. Methods In this observational pharmacokinetic study, multiple blood samples were …
patients. Methods In this observational pharmacokinetic study, multiple blood samples were …
Pharmacokinetics of short versus extended infusion meropenem dosing in critically ill patients: a pilot study
Objective: To test whether a prolonged 3-hour infusion of meropenem 500mg achieves an
equivalent proportion of time above the minimal inhibitory concentration (MIC)(% T MIC) to …
equivalent proportion of time above the minimal inhibitory concentration (MIC)(% T MIC) to …
Management of Pseudomonas aeruginosa pneumonia: one size does not fit all
In view of the mortality associated with Pseudomonas aeruginosa (PSA) ventilator-
associated pneumonia (VAP) and the frequency of inadequate initial empiric therapy, recent …
associated pneumonia (VAP) and the frequency of inadequate initial empiric therapy, recent …
[PDF][PDF] Augmented renal clearance in the critically ill: Prevalence, risk factors and implications for beta-lactam therapy
AA Udy - 2014 - core.ac.uk
Background: Beta-lactams are often used empirically in the intensive care unit (ICU), as they
possess a wide spectrum of antibacterial activity. Most agents in this class are renally …
possess a wide spectrum of antibacterial activity. Most agents in this class are renally …