Infections in critically ill patients are associated with persistently poor clinical outcomes.
These patients have severely altered and variable antibiotic pharmacokinetics and are …

Given the sparse antibiotic pipeline and the increasing prevalence of resistant organisms,
efforts should be made to optimise the pharmacodynamic exposure of currently available …

Purpose Risk factors for β-lactam antibiotic underdosing in critically ill patients have not
been described in large-scale studies. The objective of this study was to describe …

The pharmacokinetics (PK) of antimicrobial agents administered to critically ill patients
exhibit marked variability. This variability results from pathophysiological changes that occur …

Aims Significant alterations in the pharmacokinetics (PK) of antimicrobials have been
reported in critically ill patients. We describe PK parameters of imipenem in intensive care …

Infections in critically ill patients are associated with persistently poor clinical outcomes.
These patients have severely altered and variable antibiotic pharmacokinetics and are …

Objectives To investigate the population pharmacokinetics of cefuroxime in critically ill
patients. Methods In this observational pharmacokinetic study, multiple blood samples were …

Objective: To test whether a prolonged 3-hour infusion of meropenem 500mg achieves an
equivalent proportion of time above the minimal inhibitory concentration (MIC)(% T MIC) to …

In view of the mortality associated with Pseudomonas aeruginosa (PSA) ventilator-
associated pneumonia (VAP) and the frequency of inadequate initial empiric therapy, recent …

Background: Beta-lactams are often used empirically in the intensive care unit (ICU), as they
possess a wide spectrum of antibacterial activity. Most agents in this class are renally …