It can be convenient to think of the genome as simply a string of nucleotides, the linear order
of which encodes an organism's genetic blueprint. However, the genome does not exist as a …

Enhancers establish spatial or temporal patterns of gene expression that are critical for
development, yet our understanding of how these DNA cis-regulatory elements function from …

The pluripotent state of embryonic stem cells (ESCs) is produced by active transcription of
genes that control cell identity and repression of genes encoding lineage-specifying …

Epigenetic alterations, particularly in DNA methylation, are ubiquitous in cancer, yet the
molecular origins and the consequences of these alterations are poorly understood. CTCF …

The relation between alterations in chromatin structure and changes in gene expression
during cell differentiation has served as a paradigm to understand the link between genome …

The cell establishes heritable patterns of active and silenced chromatin via interacting
factors that set, remove, and read epigenetic marks. To understand how the underlying …

CCCTC-binding factor (CTCF) is the major protein involved in insulator activity in
vertebrates, with widespread DNA binding sites in the genome. CTCF participates in many …

Insulators functionally separate active chromatin domains from inactive ones. The insulator
factor, CTCF, has been found to bind to boundaries and to mediate insulator function. CTCF …

Rationale: Death from infection is a highly heritable trait, yet there are few genetic variants
with known mechanism influencing survival during septic shock. Objectives: We …

Higher order chromatin structures across the genome are maintained in part by the
architectural proteins CCCTC binding factor (CTCF) and the cohesin complex, which co …