Autophagy and apoptosis control the turnover of organelles and proteins within cells, and of
cells within organisms, respectively, and many stress pathways sequentially elicit …

Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

Radiotherapy is a major part in the treatment of most common cancers, but many patients
experience local recurrence with metastatic disease. In evaluating response biomarkers, we …

Some of the anti-neoplastic effects of anthracyclines in mice originate from the induction of
innate and T cell–mediated anticancer immune responses. Here we demonstrate that …

Blockade of colony-stimulating factor-1 (CSF-1) limits macrophage infiltration and improves
response of mammary carcinomas to chemotherapy. Herein we identify interleukin (IL)-10 …

Conventional anticancer chemotherapy has been historically thought to act through direct
killing of tumor cells. This concept stems from the fact that cytotoxic drugs interfere with DNA …

During the past decades, anticancer immunotherapy has evolved from a promising
therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now …

The immunogenic demise of cancer cells can be induced by various chemotherapeutics,
such as anthracyclines and oxaliplatin, and provokes an immune response against tumor …

Immunogenic cell death induced by anticancer chemotherapy is characterized by a series of
molecular hallmarks that include the exodus of high-mobility group box 1 protein (HMGB1) …

Oncolytic viruses are novel immunotherapeutics with increasingly promising outcomes in
cancer patient clinical trials. Preclinical and clinical studies have uncovered the importance …