Early developmental conditioning of later health and disease: physiology or pathophysiology?
MA Hanson, PD Gluckman - Physiological reviews, 2014 - journals.physiology.org
Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …
environmental influences during early development affect the risk of later pathophysiological …
Pathogenesis of idiopathic pulmonary fibrosis
PJ Wolters, HR Collard, KD Jones - Annual Review of Pathology …, 2014 - annualreviews.org
Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial lung disease associated with
aging that is characterized by the histopathological pattern of usual interstitial pneumonia …
aging that is characterized by the histopathological pattern of usual interstitial pneumonia …
Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring
Objective Differential effects of maternal and paternal posttraumatic stress disorder (PTSD)
have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor …
have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor …
Aging of blood can be tracked by DNA methylation changes at just three CpG sites
Background Human aging is associated with DNA methylation changes at specific sites in
the genome. These epigenetic modifications may be used to track donor age for forensic …
the genome. These epigenetic modifications may be used to track donor age for forensic …
Human social genomics
SW Cole - PLoS genetics, 2014 - journals.plos.org
A growing literature in human social genomics has begun to analyze how everyday life
circumstances influence human gene expression. Social-environmental conditions such as …
circumstances influence human gene expression. Social-environmental conditions such as …
[HTML][HTML] Endometriosis still a challenge
C Mehedintu, MN Plotogea, S Ionescu… - Journal of medicine …, 2014 - ncbi.nlm.nih.gov
Endometriosis is a debilitating disease with features of chronic inflammation. Endometriosis
appears to be one of the most common benign gynecological proliferations in …
appears to be one of the most common benign gynecological proliferations in …
Early life nutrition, epigenetics and programming of later life disease
MH Vickers - Nutrients, 2014 - mdpi.com
The global pandemic of obesity and type 2 diabetes is often causally linked to marked
changes in diet and lifestyle; namely marked increases in dietary intakes of high energy …
changes in diet and lifestyle; namely marked increases in dietary intakes of high energy …
Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes
E Nilsson, PA Jansson, A Perfilyev, P Volkov… - Diabetes, 2014 - Am Diabetes Assoc
Genetics, epigenetics, and environment may together affect the susceptibility for type 2
diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using …
diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using …
[HTML][HTML] The search for antiaging interventions: from elixirs to fasting regimens
The phenomenon of aging is an intrinsic feature of life. Accordingly, the possibility to
manipulate it has fascinated humans likely since time immemorial. Recent evidence is …
manipulate it has fascinated humans likely since time immemorial. Recent evidence is …
Use of epigenetic drugs in disease: an overview
S Heerboth, K Lapinska, N Snyder… - Genetics & …, 2014 - journals.sagepub.com
Epigenetic changes such as DNA methylation and histone methylation and acetylation alter
gene expression at the level of transcription by upregulating, downregulating, or silencing …
gene expression at the level of transcription by upregulating, downregulating, or silencing …