Acute post-asphyxial encephalopathy occurring around the time of birth remains a major
cause of death and disability. The recent seminal insight that allows active neuroprotective …

There is now compelling clinical evidence from meta-analyses of large randomized
controlled trials that in term infants with moderate to severe hypoxia-ischemia (HI) …

Background In the Total Body Hypothermia for Neonatal Encephalopathy Trial (TOBY),
newborns with asphyxial encephalopathy who received hypothermic therapy had improved …

Objective Seizures are common among newborns with hypoxic-ischaemic encephalopathy
(HIE) but the relationship between seizure burden and severity of brain injury among …

Background Erythropoietin is neuroprotective in animal models of neonatal hypoxic-
ischemic encephalopathy. We previously reported a phase I safety and pharmacokinetic …

Background: We hypothesized that acute kidney injury (AKI) in asphyxiated neonates
treated with therapeutic hypothermia would be associated with hypoxic–ischemic lesions on …

Hypoxic-ischemic injury (HII) continues to be an important cause of neonatal mortality and
morbidity. In recent years, the role of magnetic resonance (MR) imaging has increased by …

Abstract Background Despite therapeutic hypothermia 30-70% of newborns with moderate
or severe hypoxic ischemic encephalopathy will die or survive with significant long-term …

Aim To compare diffusion-weighted imaging (DWI) and non-DWI magnetic resonance
imaging (MRI), proton MR spectroscopy (1H-MRS), and clinical biomarkers for prediction of …

Background Newborns with hypoxic ischemic encephalopathy (HIE) are at risk for
coagulopathy due to systemic oxygen deprivation. Additionally, therapeutic hypothermia …