Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

S Mitragotri, PA Burke, R Langer - Nature reviews Drug discovery, 2014 - nature.com
The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies
and recombinant proteins, poses substantial challenges owing to their large size and …

An overview of clinical and commercial impact of drug delivery systems

AC Anselmo, S Mitragotri - Journal of Controlled Release, 2014 - Elsevier
Drug delivery systems are widely researched and developed to improve the delivery of
pharmaceutical compounds and molecules. The last few decades have seen a marked …

HCV transmission in industrialized countries and resource-constrained areas

M Thursz, A Fontanet - Nature reviews Gastroenterology & hepatology, 2014 - nature.com
HCV is a blood-borne virus transmitted by percutaneous exposure to infected blood or blood-
derived body fluids. The main routes of transmission are blood transfusions, medical …

Assessment of prevalence and determinants of occupational exposure to HIV infection among healthcare workers in selected health institutions in Debre Berhan town …

F Aynalem Tesfay… - AIDS research and …, 2014 - Wiley Online Library
Introduction. Health care workers are exposed to different kinds of occupational hazards due
to their day to day activities. The most common occupational exposure like body fluids is a …

Efficacy of imiquimod-based transcutaneous immunization using a nano-dispersed emulsion gel formulation

P Stein, K Gogoll, S Tenzer, H Schild, S Stevanovic… - PloS one, 2014 - journals.plos.org
Background Transcutaneous immunization (TCI) approaches utilize skin associated
lymphatic tissues to elicit specific immune responses. In this context, the imidazoquinoline …

[HTML][HTML] KASL clinical practice guidelines: management of hepatitis C

Korean Association for the Study of the … - Clinical and …, 2014 - ncbi.nlm.nih.gov
Aims Practice Guidelines for Management of Hepatitis C were first established in 2004.
Since then, many study results have been published concerned with epidemiology, clinical …

Intranasal co-delivery of IL-6 gene enhances the immunogenicity of anti-caries DNA vaccine

L Su, F Yu, Z Li, C Zeng, Q Xu, M Fan - Acta Pharmacologica Sinica, 2014 - nature.com
Aim: To investigate the effects of co-delivering IL-6 expressing plasmid pCI-IL-6 on the
immunogenicity of the anti-caries DNA vaccine pCIA-P, which encodes the surface protein …

Transepithelial transport of PAMAM dendrimers across isolated rat jejunal mucosae in ussing chambers

D Hubbard, H Ghandehari, DJ Brayden - Biomacromolecules, 2014 - ACS Publications
Oral delivery remains a challenge for poorly permeable hydrophilic macromolecules. Poly
(amido amine)(PAMAM) dendrimers have shown potential for their possible oral delivery …

Toward intradermal vaccination: preparation of powder formulations by collapse freeze-drying

EE Etzl, G Winter, J Engert - Pharmaceutical development and …, 2014 - Taylor & Francis
Intradermal powder immunization is an emerging technique in vaccine delivery. The
purpose of this study was to generate powder particles for intradermal injection by freeze …

Medical injection use among adults and adolescents aged 15 to 64 years in Kenya: results from a national survey

D Kimani, R Kamau, V Ssempijja… - JAIDS Journal of …, 2014 - journals.lww.com
Background: Unsafe medical injections remain a potential route of HIV transmission in
Kenya. We used data from a national survey in Kenya to study the magnitude of medical …