Objective: Suicide, a major cause of death worldwide, has distinct biological underpinnings.
The authors review and synthesize the research literature on biomarkers of suicide, with the …

Background It is widely acknowledged that suicidal behavior (SB) has a genetic influence.
As a consequence, molecular genetic studies have been mostly conducted on serotonergic …

Women exhibit a nearly twofold increased risk of developing depression and anxiety
disorders when compared to men, a fact that has been hypothesized to result in part from …

Suicidal behaviors are observed across most of the life span, beginning in late childhood. At
present, however, few life span developmental studies of suicide risk have appeared in the …

Early reports of clinical utility are published. The current evidence base for antidepressant
pharmacogenetics is, however, not yet empirically robust enough to inform routine …

In the last years, serotonin (5-HT) has been related with the pathophysiology of several
psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5 …

Meta-analysis of polymorphisms in TPH2 gene and suicidal behavior Meta-analysis of
polymorphisms in TPH2 gene and suicidal behavior Psychiatry Res. 2014 Dec 30;220(3):1163-6 …

Abstract Human TPH2 (hTPH 2) catalyzes the ratelimiting step in CNS serotonin
biosynthesis. We characterized a singlenucleotide polymorphism (C2755A) in the hTPH 2 …

Suicidal behavior comprises a range of heterogeneous entities, from completed suicide to
suicide attempts to suicidal ideation (Mann 1998). While the causes of suicide are complex …

The incidence of suicidal deaths make it an issue of grave concern and a potentially
dangerous public health predicament as it is among the leading causes of death among …