Micronucleus assay with urine derived cells (UDC): a review of its application in human studies investigating genotoxin exposure and bladder cancer risk

A Nersesyan, M Kundi, M Fenech, C Bolognesi… - … Research/Reviews in …, 2014 - Elsevier
The first micronucleus (MN) study with urine derived cells (UDC) appeared 30 years ago. So
far, 56 investigations have been published with this method and it was shown that it can be …

Микроядерный тест буккального эпителия ротовой полости человека: проблемы, достижения, перспективы

ВН Калаев, ВГ Артюхов, МС Нечаева - Цитология и генетика, 2014 - irbis-nbuv.gov.ua
Проанализированы статьи российских и зарубежных авторов за 2000–2012 гг.,
посвященные проблемам применения, анализа и интерпретации результатов …

Assessment of genotoxic effects in nurses handling cytostatic drugs

C Ladeira, S Viegas, M Pádua, M Gomes… - Journal of Toxicology …, 2014 - Taylor & Francis
Several antineoplastic drugs have been classified as carcinogens by the International
Agency for Research on Cancer (IARC) on the basis of epidemiological findings, animal …

Micronucleus frequency in human peripheral blood lymphocytes as a biomarker for the early detection of colorectal cancer risk

F Maffei, JM Zolezzi Moraga, S Angelini… - …, 2014 - academic.oup.com
The early detection of colorectal cancer (CRC) can significantly improve the prognosis of
affected patients. The loss of genomic stability and the resulting gene alteration play an …

Evaluation of chromosome aberration and micronucleus frequencies in blood lymphocytes of workers exposed to low concentrations of benzene

P Lovreglio, F Maffei, M Carrieri, MN D'Errico… - … /Genetic Toxicology and …, 2014 - Elsevier
The frequency of chromosome aberrations (CA) and micronuclei (MN) was investigated in
the peripheral lymphocytes of workers occupationally exposed to low or very low …

Cytogenetic endpoints and Xenobiotic gene polymorphism in lymphocytes of hospital workers chronically exposed to ionizing radiation in Cardiology, Radiology and …

B Vellingiri, S Shanmugam, MD Subramaniam… - Ecotoxicology and …, 2014 - Elsevier
Ionizing radiation (IR) is known as a classical mutagen capable of inducing various kinds of
stable and unstable chromosomal aberrations (CA) including the possibility of increasing the …

Increased genome instability and oxidative DNA damage and their association with IGF-1 levels in patients with active acromegaly

F Bayram, N Bitgen, H Donmez-Altuntas, I Cakir… - Growth Hormone & IGF …, 2014 - Elsevier
Objective The objectives of this study were to assess cytokinesis-block micronucleus cytome
(CBMN Cyt) assay parameters and also oxidative DNA damage in patients with active …

Genotoxic, cytotoxic, and apoptotic effects of Hypogymnia physodes (L.) Nyl. on breast cancer cells

F Ari, S Celikler, S Oran, N Balikci… - Environmental …, 2014 - Wiley Online Library
The aim of this study is to determine the chemical composition, and evaluate the genotoxic,
and anti‐growth potency of the methanol extracts of lichen species Hypogymnia physodes …

Clinical application of micronucleus test: a case-control study on the prediction of breast cancer risk/susceptibility

C Bolognesi, P Bruzzi, V Gismondi, S Volpi… - PLoS …, 2014 - journals.plos.org
The micronucleus test is a well-established DNA damage assay in human monitoring. The
test was proposed as a promising marker of cancer risk/susceptibility mainly on the basis of …

Assessing the suitability of 8-OHdG and micronuclei as genotoxic biomarkers in chromate-exposed workers: a cross-sectional study

P Li, Y Gu, S Yu, Y Li, J Yang, G Jia - BMJ open, 2014 - bmjopen.bmj.com
Objectives We aimed to investigate suitable conditions of 8-hydroxy-2′-deoxyguanosine (8-
OHdG) and micronucleus (MN) as genotoxic biomarkers at different levels of occupational …