The actions of catecholamines on adrenergic receptors (ARs) induce sympathetic
responses, and sustained activation of the sympathetic nervous system results in disrupted …

Apoptosis signal–regulating kinase 1 (ASK1, also known as MAP3K5) mediates reactive
oxygen species (ROS)–induced cell death. When activated by ROS, ASK1 ultimately …

The response to insulin is impaired in type 2 diabetes. Much information is available about
insulin signaling, but understanding of the cellular mechanisms causing impaired signaling …

Trp-Asp (WD) repeat protein 68 (WDR68) is an evolutionarily conserved WD40 repeat
protein that binds to several proteins, including dual specificity tyrosine phosphorylation …

The p38 MAPK signal transduction pathway plays an important role in inflammatory and
stress responses. MAPKK6 (MKK6), a dual specificity protein kinase, is a p38 activator …

Unlike the other MAP 3Ks, MEKK 1 (encoded by Map3k1) contains a PHD motif. To
understand the role of this motif, we have created a knockin mutant of mouse Map3k1 …

Recent studies implicate the muscle-specific ubiquitin ligase muscle RING finger-1 (MuRF1)
in inhibiting pathological cardiomyocyte growth in vivo by inhibiting the transcription factor …

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease that has a
considerable impact on the quality of life. Alterations in signalling pathways may contribute …

Post-transcriptional regulation of gene expression takes place at multiple levels between
transcription and decay of the mRNA. RNA-binding proteins play a key role in orchestrating …

During the process of fertilization, a series of events that are essential for later development
occur, including an intracellular Ca 2+ increase, elevation of the fertilization envelope …