Recent advances in delivery through the blood-brain barrier

JM Larsen, DR Martin… - Current topics in medicinal …, 2014 - ingentaconnect.com
Current routes of delivering therapeutics to the brain to treat a variety of neurologic
conditions include intracerebral, intrathecal, and intranasal delivery. Though successes …

[HTML][HTML] Selective neuronal differentiation of neural stem cells induced by nanosecond microplasma agitation

Z Xiong, S Zhao, X Mao, X Lu, G He, G Yang, M Chen… - Stem Cell Research, 2014 - Elsevier
An essential step for therapeutic and research applications of stem cells is their ability to
differentiate into specific cell types. Neuronal cells are of great interest for medical treatment …

Advances toward regenerative medicine in the central nervous system: challenges in making stem cell therapy a viable clinical strategy

EA Stoll - Molecular and cellular therapies, 2014 - Springer
Over recent years, there has been a great deal of interest in the prospects of stem cell-based
therapies for the treatment of nervous system disorders. The eagerness of scientists …

3D porous chitosan scaffolds suit survival and neural differentiation of dental pulp stem cells

X Feng, X Lu, D Huang, J Xing, G Feng, G Jin… - Cellular and molecular …, 2014 - Springer
A key aspect of cell replacement therapy in brain injury treatment is construction of a suitable
biomaterial scaffold that can effectively carry and transport the therapeutic cells to the target …

Embryonic-like stem cells derived from adult human peripheral blood and methods of use

Y Zhao, T Mazzone - US Patent 8,835,163, 2014 - Google Patents
The present invention is related generally to embryonic-like stem cells isolated from adult
human peripheral blood, des ignated herein as peripheral blood-stem cells (PB-SC), which …

Maintenance and neuronal cell differentiation of neural stem cells C17. 2 correlated to medium availability sets design criteria in microfluidic systems

B Wang, S Jedlicka, X Cheng - PLoS One, 2014 - journals.plos.org
Background Neural stem cells (NSCs) play an important role in developing potential cell-
based therapeutics for neurodegenerative disease. Microfluidics has proven a powerful tool …

Multifaceted roles of BDNF and FGF2 in human striatal primordium development. An in vitro study

E Sarchielli, M Marini, S Ambrosini, A Peri… - Experimental …, 2014 - Elsevier
Grafting fetal striatal cells into the brain of Huntington's disease (HD) patients has raised
certain expectations in the past decade as an effective cell-based-therapy for this …

Primate adult brain cell autotransplantation produces behavioral and biological recovery in 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine‐induced parkinsonian St …

J Bloch, JF Brunet, CRS McEntire… - Journal of …, 2014 - Wiley Online Library
The potential for “replacement cells” to restore function in Parkinson's disease has been
widely reported over the past 3 decades, rejuvenating the central nervous system rather …

Anticonvulsant effects by bilateral and unilateral transplantation of GABA-producing cells into the subthalamic nucleus in an acute seizure model

A Handreck, B Backofen-Wehrhahn… - Cell …, 2014 - journals.sagepub.com
Neural transplantation of GABA-producing cells into key structures within seizure-
suppressing circuits holds promise for medication-resistant epilepsy patients not eligible for …

Mesenchymal stem cell therapy for neurodegenerative diseases

L Chen, R Qiu, Q Xu - Journal of Nanoscience and …, 2014 - ingentaconnect.com
This paper reviews the recent studies and development of mesenchymal stem cell (MSCs)
therapy for neurodegenerative diseases. MSCs transplantation, a promising therapy, can …