Genes in which germline mutations confer highly or moderately increased risks of cancer
are called cancer predisposition genes. More than 100 of these genes have been identified …

Thyroid cancer is rapidly increasing in incidence, but the mortality rate remains flat. Debate
has arisen over the need to detect or treat most thyroid cancers early, given their favorable …

BTA_Guidelines_for_the_Management_of_Thyroid Cancer_E Page 1 CLINICAL
ENDOCRINOLOGY VOLUME 81 SUPPLEMENT 1 JULY 2014 THE CLINICAL JOURNAL OF …

Alectinib/CH5424802 is a known inhibitor of anaplastic lymphoma kinase (ALK) and is being
evaluated in clinical trials for the treatment of ALK fusion–positive non–small cell lung …

Thyroid cancers are the most frequent neoplasms of the endocrine system and in the initial
stages their prognosis is excellent. However, few therapeutic options are available for …

Background Vascular endothelial growth factor tyrosine-kinase inhibitors (VEGFR-TKIs)
have emerged as an effective targeted therapy in the treatment of cancer patients, the …

Introduction: Medullary thyroid carcinoma (MTC) originates in the thyroid parafollicular cells
and represents 3-4% of the malignant neoplasms that affect this gland. Approximately 25 …

Abstract About 10–15% of adult gastrointestinal stromal tumors (GISTs) and 85% of pediatric
GISTs do not have mutations in the KIT or PDGFRA genes and are generally classified as …

Medullary thyroid cancer (MTC) is an aggressive form of thyroid cancer that occurs in both
heritable and sporadic forms. Discovery that mutations in the rearranged during transfection …

The destruction of proteins via the ubiquitin–proteasome system is a multi-step, complex
process involving polyubiquitination of substrate proteins, followed by proteolytic …