Pax-8–PPAR-γ fusion protein in thyroid carcinoma

P Raman, RJ Koenig - Nature Reviews Endocrinology, 2014 - nature.com
Thyroid carcinoma is the most common endocrine malignancy, and its incidence is
continuing to increase. Most thyroid carcinomas contain one of several known driver …

[HTML][HTML] Molecular approaches to thyroid cancer diagnosis

SJ Hsiao, YE Nikiforov - Endocrine-related cancer, 2014 - erc.bioscientifica.com
Thyroid nodules are common, and the accurate diagnosis of cancer or benign disease is
important for the effective clinical management of patients. Molecular markers are a helpful …

p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer

DG McFadden, A Vernon… - Proceedings of the …, 2014 - National Acad Sciences
Anaplastic thyroid carcinoma (ATC) has among the worst prognoses of any solid
malignancy. The low incidence of the disease has in part precluded systematic clinical trials …

Deregulation of microRNA expression in thyroid neoplasias

P Pallante, S Battista, GM Pierantoni… - Nature Reviews …, 2014 - nature.com
MicroRNAs (miRNAs) have emerged as a class of powerful gene expression regulators.
Acting at the post-transcriptional level, miRNAs modulate the expression of at least one-third …

An update on molecular biology of thyroid cancers

O Omur, Y Baran - Critical reviews in oncology/hematology, 2014 - Elsevier
Differentiated thyroid cancer (DTC) is the most common endocrinological malignancy. There
are several histological variants such as papillary and follicular thyroid carcinoma. Many …

[HTML][HTML] p53: the barrier to cancer stem cell formation

R Aloni-Grinstein, Y Shetzer, T Kaufman, V Rotter - FEBS letters, 2014 - Elsevier
The role of p53 as the “guardian of the genome” in differentiated somatic cells, triggering
various biological processes, is well established. Recent studies in the stem cell field have …

The paradigm of mutant p53-expressing cancer stem cells and drug resistance

Y Shetzer, H Solomon, G Koifman… - …, 2014 - academic.oup.com
It is well accepted that expression of mutant p53 involves the gain of oncogenic-specific
activities accentuating the malignant phenotype. Depending on the specific cancer type …

MicroRNA deregulation in anaplastic thyroid cancer biology

CS Fuziwara, ET Kimura - International journal of …, 2014 - Wiley Online Library
Anaplastic thyroid cancer (ATC) is among the most lethal types of cancers, characterized as
a fast‐growing and highly invasive thyroid tumor that is unresponsive to surgery and …

Genetics and epigenetics of sporadic thyroid cancer

D Vu-Phan, RJ Koenig - Molecular and cellular endocrinology, 2014 - Elsevier
Thyroid carcinoma is the most common endocrine malignancy, and although the disease
generally has an excellent prognosis, therapeutic options are limited for patients not cured …

Novel approaches in anaplastic thyroid cancer therapy

KT Hsu, XM Yu, AW Audhya, JC Jaume… - The …, 2014 - academic.oup.com
Anaplastic thyroid cancer (ATC), accounting for less than 2% of all thyroid cancer, is
responsible for the majority of death from all thyroid malignancies and has a median survival …